专利检索 ap:("WEST CHINA HOSPITAL, SICHUAN UNIVERSITY") AND inv:"Xiaofeng LU" 第 1 页

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发明申请
FUSION PROTEIN CONTAINING TRAIL AND IGG BINDING DOMAIN AND THE USES THEREOF 有权

公开(公告)号：US20210101944A1

公开(公告)日：2021-04-08

申请号：US16989654

申请日：2020-08-10

申请人： WEST CHINA HOSPITAL, SICHUAN UNIVERSITY

发明人： Xiaofeng LU , Hao YANG , Ze TAO , Jingqiu CHENG

IPC分类号： C07K14/315 , C07K14/705 , C07K16/28 , A61K38/17 , A61K38/16 , A61P35/00

摘要： A recombinant protein includes a TRAIL domain and an IgG binding domain IgBD. In the recombinant protein, IgBD can be fused at the N-terminus or C-terminus of the TRAIL domain. The anti-tumor effect of the recombinant protein after binding to endogenous or exogenous IgG is significantly stronger than that of TRAIL, and can be used in the treatment of cell proliferative diseases with high expression of death receptors.