公开(公告)号：US20190263765A1

公开(公告)日：2019-08-29

申请号：US16282941

申请日：2019-02-22

Applicant: WISYS TECHNOLOGY FOUNDATION, INC.

Inventor： David E. Lewis

IPC: C07D303/06 ,  C07D303/31 ,  A61K31/37 ,  A61P7/02

Abstract: A composition is provided that, when utilized in combination with a coumarin anticoagulant, greatly improves the anticoagulant effects of the anticoagulant in mammalian subjects. The composition is a compound having a naphthohydroquinone ring system substantially similar to the ring system of the reduced form of vitamin K1 and has the general formula: where n is 1 or 2, where R1 and R4 are hydrogen or acyl, R2 is a hydrogen or saturated or unsaturated alkyl group with up to 6 carbons, and R3 is a hydrogen or saturated or unsaturated alkyl group with up to 6 carbons, or R2 and R3 are part of a cyclic or polycyclic ring system.