公开(公告)号：US20240101668A1

公开(公告)日：2024-03-28

申请号：US18447138

申请日：2023-08-09

申请人： WUGEN, Inc.

发明人： Ayman KABAKIBI ,  Alexander S. HAMIL

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P37/04 ,  C12N15/86

CPC分类号： C07K16/2803 ,  A61K39/4611 ,  A61K39/4631 ,  A61P37/04 ,  C07K16/2851 ,  C07K16/2863 ,  C12N15/86 ,  A61K2239/11 ,  A61K2239/21 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/622 ,  C12N2740/15043

摘要： Disclosed herein are polypeptides, such as monoclonal antibodies (mAbs) and functional fragments thereof, synthetic antigen-binding proteins such as single-chain variable fragments (scFvs), and chimeric antigen receptors (CARs), that can specifically recognize tumor-associated antigens (TAAs) on cancer cells, for example those that express CD33, FLT3, and CLL-1, useful in the treatment of diseases such as cancer.