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公开(公告)号：US20140235835A1
公开(公告)日：2014-08-21
申请号：US14201184
申请日：2014-03-07
申请人： WYETH HOLDINGS LLC
发明人： ARTHUR KUNZ , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
IPC分类号： A61K47/48 , A61K31/704
CPC分类号： A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译： 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数（LCF）的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物，包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物，包含缀合物的组合物和缀合物的用途。
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公开(公告)号：US09351986B2
公开(公告)日：2016-05-31
申请号：US14201184
申请日：2014-03-07
申请人： WYETH HOLDINGS LLC
发明人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis DiJoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
IPC分类号： A61K47/48 , A61K31/704
CPC分类号： A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译： 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数（LCF）的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物，包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物，包含缀合物的组合物和缀合物的用途。
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公开(公告)号：US20180339058A1
公开(公告)日：2018-11-29
申请号：US16048511
申请日：2018-07-30
申请人： Wyeth Holdings LLC
发明人： Arthur KUNZ , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
摘要： Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
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公开(公告)号：US20160303252A1
公开(公告)日：2016-10-20
申请号：US15145238
申请日：2016-05-03
申请人： Wyeth Holdings LLC
发明人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
CPC分类号： A61K31/704 , A61K47/48507 , A61K47/64 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译： 描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数（LCF）的药物负载的单体细胞毒性药物/载体缀合物的方法。 还描述了细胞毒性药物衍生物/抗体缀合物，包含缀合物的组合物和缀合物的用途。 还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物，包含缀合物的组合物和缀合物的用途。
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