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公开(公告)号：US08299023B2
公开(公告)日：2012-10-30
申请号：US12547076
申请日：2009-08-25
申请人： Waleed Danho , David Charles Fry , Robert Alan Goodnow, Jr. , Wajiha Khan , Joseph Swistok , Jefferson Wright Tilley
发明人： Waleed Danho , David Charles Fry , Robert Alan Goodnow, Jr. , Wajiha Khan , Joseph Swistok , Jefferson Wright Tilley
IPC分类号： A61K38/10
CPC分类号： C07K14/57545 , A61K38/00
摘要： Provided herein are neuropeptide-2 receptor agonists of the formula (I): Y—R1—R2—X—R3—R4—R5—R6—R7—R8—R9—R10—R11—R12—R13—R14—NH2 (I) (SEQ ID NO: 1), as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
摘要翻译： 本文提供式（I）的神经肽-2受体激动剂：Y-R1-R2-X-R3-R4-R5-R6-R7-R8-R9-R10-R11-R12-R13-R14-NH2 ）（SEQ ID NO：1），以及其药学上可接受的盐，衍生物和片段，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症和糖尿病。
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公开(公告)号：US20100069307A1
公开(公告)日：2010-03-18
申请号：US12547076
申请日：2009-08-25
申请人： Waleed Danho , David Charles Fry , Robert Alan Goodnow, JR. , Wajiha Khan , Joseph Swistok , Jefferson Wright Tilley
发明人： Waleed Danho , David Charles Fry , Robert Alan Goodnow, JR. , Wajiha Khan , Joseph Swistok , Jefferson Wright Tilley
CPC分类号： C07K14/57545 , A61K38/00
摘要： Provided herein are neuropeptide-2 receptor agonists of the formula (I): Y—R1—R2—X—R3—R4—R5—R6—R7—R8—R9—R10—R11—R12—R13—R14—NH2 (I), as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
摘要翻译： 本文提供式（I）的神经肽-2受体激动剂：Y-R1-R2-X-R3-R4-R5-R6-R7-R8-R9-R10-R11-R12-R13-R14-NH2 ），以及其药学上可接受的盐，衍生物和片段，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症和糖尿病。
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公开(公告)号：US07642244B2
公开(公告)日：2010-01-05
申请号：US11607230
申请日：2006-12-01
申请人： Karin Conde-Knape , Waleed Danho , George Ehrlich , Nader Fotouhi , David Charles Fry , Wajiha Khan , Anish Konkar , Cristina Martha Rondinone , Joseph Swistok , Rebecca Anne Taub , Jefferson Wright Tilley
发明人： Karin Conde-Knape , Waleed Danho , George Ehrlich , Nader Fotouhi , David Charles Fry , Wajiha Khan , Anish Konkar , Cristina Martha Rondinone , Joseph Swistok , Rebecca Anne Taub , Jefferson Wright Tilley
CPC分类号： C07K14/57545 , A61K38/00 , A61K47/60
摘要： Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. X is 4-oxo-6-(1-piperazinyl)-3(4H)-quinazoline-acetic acid (Pqa). These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
摘要翻译： 本文提供了式（I）的神经肽-2受体激动剂：以及其药学上可接受的盐，衍生物和片段，其中取代基如说明书中公开的那些。 X是4-氧代-6-（1-哌嗪基）-3（4H） - 喹唑啉 - 乙酸（Pqa）。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症和糖尿病。
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公开(公告)号：US08268784B2
公开(公告)日：2012-09-18
申请号：US12536688
申请日：2009-08-06
申请人： Karin Conde-Knape , Waleed Danho , George Ehrlich , Nader Fotouhi , David Charles Fry , Wajiha Khan , Anish Konkar , Cristina Martha Rondinone , Joseph Swistok , Rebecca Anne Taub , Jefferson Wright Tilley
发明人： Karin Conde-Knape , Waleed Danho , George Ehrlich , Nader Fotouhi , David Charles Fry , Wajiha Khan , Anish Konkar , Cristina Martha Rondinone , Joseph Swistok , Rebecca Anne Taub , Jefferson Wright Tilley
CPC分类号： C07K14/57545 , A61K38/00 , A61K47/60
摘要： Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. X is 4-oxo-6-(1-piperazinyl)-3(4H)-quinazoline-acetic acid (Pqa). These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
摘要翻译： 本文提供了式（I）的神经肽-2受体激动剂：以及其药学上可接受的盐，衍生物和片段，其中取代基如说明书中公开的那些。 X是4-氧代-6-（1-哌嗪基）-3（4H） - 喹唑啉 - 乙酸（Pqa）。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症和糖尿病。
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公开(公告)号：US20110172147A1
公开(公告)日：2011-07-14
申请号：US13072048
申请日：2011-03-25
申请人： Karin Conde-Knape , Waleed Danho , Nader Fotouhi , David Charles Fry , Wajiha Khan , Anish Konkar , Cristina Martha Rondinone , Joseph Swistok , Jefferson Wright Tilley
发明人： Karin Conde-Knape , Waleed Danho , Nader Fotouhi , David Charles Fry , Wajiha Khan , Anish Konkar , Cristina Martha Rondinone , Joseph Swistok , Jefferson Wright Tilley
CPC分类号： C07K14/575 , A61K38/00 , C07K14/57545
摘要： Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
摘要翻译： 本文提供了式（I）的神经肽-2受体激动剂：以及其药学上可接受的盐，衍生物和片段，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症和糖尿病。
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公开(公告)号：US20100179093A1
公开(公告)日：2010-07-15
申请号：US12610417
申请日：2009-11-02
申请人： Waleed Danho , Nader Fotouhi , David Charles Fry , Wajiha Khan , Joseph Swistok , Jefferson Wright Tilley
发明人： Waleed Danho , Nader Fotouhi , David Charles Fry , Wajiha Khan , Joseph Swistok , Jefferson Wright Tilley
CPC分类号： A61K38/2271
摘要： Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
摘要翻译： 本文提供了式（I）的神经肽-2受体激动剂：以及其药学上可接受的盐，衍生物和片段，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症和糖尿病。
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公开(公告)号：US20100137223A1
公开(公告)日：2010-06-03
申请号：US12536688
申请日：2009-08-06
申请人： Karin Conde-Knape , Waleed Danho , George Ehrlich , Nader Fotouhi , David Charles Fry , Wajiha Khan , Anish Konkar , Cristina Martha Rondinone , Joseph Swistok , Rebecca Anne Taub , Jefferson Wright Tilley
发明人： Karin Conde-Knape , Waleed Danho , George Ehrlich , Nader Fotouhi , David Charles Fry , Wajiha Khan , Anish Konkar , Cristina Martha Rondinone , Joseph Swistok , Rebecca Anne Taub , Jefferson Wright Tilley
CPC分类号： C07K14/57545 , A61K38/00 , A61K47/60
摘要： Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. X is 4-oxo-6-(1-piperazinyl)-3(4H)-quinazoline-acetic acid (Pqa). These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
摘要翻译： 本文提供了式（I）的神经肽-2受体激动剂：以及其药学上可接受的盐，衍生物和片段，其中取代基如说明书中公开的那些。 X是4-氧代-6-（1-哌嗪基）-3（4H） - 喹唑啉 - 乙酸（Pqa）。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症和糖尿病。
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