公开(公告)号：US10709814B2

公开(公告)日：2020-07-14

申请号：US15135997

申请日：2016-04-22

申请人： Warsaw Orthopedic, Inc.

发明人： Scott M Vickers ,  Jeffrey L Scifert ,  Mirian Gillissen ,  Didier Billy

IPC分类号： A61L27/46 ,  A61L27/24 ,  A61L27/26 ,  A61L27/50 ,  A61L27/54 ,  B29B7/00 ,  B29K309/02 ,  B29L31/00

摘要： Methods for making an osteoimplant are provided. In one embodiment the method includes applying a mechanical force to an aqueous slurry of insoluble collagen fibers to entangle the insoluble collagen fibers so as to form a semi-solid mass of entangled insoluble collagen fibers; and lyophilizing the semi-solid mass of entangled collagen fibers to form the osteoimplant. An osteoimplant containing entangled insoluble collagen fibers is also provided.