公开(公告)号：US20190169691A1

公开(公告)日：2019-06-06

申请号：US16274579

申请日：2019-02-13

申请人： Washington State University ,  Seattle Children's Hospital DBA Seatlle Children's Research Institute

发明人： Michael K. Skinner ,  Margarett Shnorhavorian

IPC分类号： C12Q1/6883

摘要： Provided herein are epigenetic modifications that are associated with prior exposure to chemotherapy agents. In particular, differential DNA methylation regions (DMRs) that are characteristic of, and can thus be used to identify and/or treat, a male subject who has undergone chemotherapy are provided. The DMRs are used to screen for pregnancy complications, infertility, and passage of heritable mutations to an infant.

公开(公告)号：US20210071253A1

公开(公告)日：2021-03-11

申请号：US16939287

申请日：2020-07-27

申请人： Washington State University ,  Seattle Children's Hospital DBA Seattle Children's Research Institute

发明人： Michael K. Skinner ,  Margarett Shnorhavorian

IPC分类号： C12Q1/6883

摘要： Provided herein are epigenetic modifications that are associated with prior exposure to chemotherapy agents. In particular, differential DNA methylation regions (DMRs) that are characteristic of, and can thus be used to identify and/or treat, a male subject who has undergone chemotherapy are provided. The DMRs are used to screen for pregnancy complications, infertility, and passage of heritable mutations to an infant.

公开(公告)号：US20220364176A1

公开(公告)日：2022-11-17

申请号：US17870886

申请日：2022-07-22

申请人： Washington State University ,  Seattle Children's Hospital DBA Seattle Children's Research Institute

发明人： Michael K. Skinner ,  Margarett Shnorhavorian

IPC分类号： C12Q1/6883

摘要： Provided herein are epigenetic modifications that are associated with prior exposure to chemotherapy agents. In particular, differential DNA methylation regions (DMRs) that are characteristic of, and can thus be used to identify and/or treat, a male subject who has undergone chemotherapy are provided. The DMRs are used to screen for pregnancy complications, infertility, and passage of heritable mutations to an infant.

公开(公告)号：US20170253927A1

公开(公告)日：2017-09-07

申请号：US15446028

申请日：2017-03-01

申请人： Washington State University ,  Seattle Children's Hospital DBA Seattle Children's Research Institute

发明人： Michael K. Skinner ,  Margarett Shnorhavorian

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/154

摘要： Provided herein are epigenetic modifications that are associated with prior exposure to chemotherapy agents. In particular, differential DNA methylation regions (DMRs) that are characteristic of, and can thus be used to identify and/or treat, a male subject who has undergone chemotherapy are provided. The DMRs are used to screen for pregnancy complications, infertility, and passage of heritable mutations to an infant.