公开(公告)号：US20130226468A1

公开(公告)日：2013-08-29

申请号：US13729175

申请日：2012-12-28

Applicant: WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Michael K. Skinner ,  Carlos M. Guerrero-Bosagna

IPC: G06F19/22

CPC classification number: G06F19/22 ,  C12Q1/68 ,  C12Q1/6827 ,  C12Q1/6869 ,  G06F19/18

Abstract: CpG densities and sequence motifs that are characteristic of regions of DNA associated with epimutations and control of epimutations are provided. Such regions include, within approximately 400 (or fewer) base pairs, at least one, usually two, and preferably all three of the following features: i) a CpG density of 15% or less; ii) the presence of the sequence motif ATTTGTTTTTTCTTTTnT (SEQ ID NO: 1) where n is A, T, C or G, and statistically relevant variants thereof; and iii) the presence of the sequence motif GGGGGnGGGG (SEQ ID NO: 2), where n is A, T, C or G, and statistically relevant variants thereof.

Abstract translation: 提供了与突变相关的DNA区域和突变的控制特征的CpG密度和序列基序。 这样的区域包括在约400个（或更少）碱基对内，至少一个，通常两个，优选全部三个以下特征：i）CpG密度为15％或更小; ii）序列基序ATTTGTTTTTTCTTTTnT（SEQ ID NO：1）的存在，其中n是A，T，C或G，以及其统计学上相关的变体; 和iii）序列基序GGGGGnGGGG（SEQ ID NO：2）的存在，其中n是A，T，C或G，以及其统计学上相关的变体。

公开(公告)号：US09734283B2

公开(公告)日：2017-08-15

申请号：US13729175

申请日：2012-12-28

Applicant: Washington State University Research Foundation

Inventor： Michael K. Skinner ,  Carlos M. Guerrero-Bosagna

IPC: C12Q1/68 ,  G06F19/22 ,  G06F19/18

CPC classification number: G06F19/22 ,  C12Q1/68 ,  C12Q1/6827 ,  C12Q1/6869 ,  G06F19/18

Abstract: CpG densities and sequence motifs that are characteristic of regions of DNA associated with epimutations and control of epimutations are provided. Such regions include, within approximately 400 (or fewer) base pairs, at least one, usually two, and preferably all three of the following features: i) a CpG density of 15% or less; ii) the presence of the sequence motif ATTTGTTTTTTCTTTTnT (SEQ ID NO: 1) where n is A, T, C or G, and statistically relevant variants thereof; and iii) the presence of the sequence motif GGGGGnGGGG (SEQ ID NO: 2), where n is A, T, C or G, and statistically relevant variants thereof.