公开(公告)号：US20240384273A1

公开(公告)日：2024-11-21

申请号：US18667824

申请日：2024-05-17

Applicant: Wave Life Sciences Ltd.

Inventor： Chandra Vargeese ,  Naoki Iwamoto ,  Wei Liu ,  Mugdha Bedekar ,  Brett Schrand ,  Priyank Shiva Prakasha ,  Anthony Lamattina ,  Luciano H. Apponi

IPC: C12N15/113

Abstract: The present disclosure provides HSD17B13-related double stranded oligonucleotides, compositions, and methods of using such double stranded oligonucleotides and compositions for preventing and/or treating various conditions, disorders, or diseases associated with expression of HSD17B13. In some embodiments, the provided double stranded oligonucleotides and compositions comprise nucleobase modifications, sugar modifications, internucleotidic linkage modifications and/or patterns thereof, and have improved properties, activities and/or selectivities. In some embodiments, the provided double stranded oligonucleotides and compositions target HSD17B13.