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    Protein tyrosine kinase inhibitors
    1.
    发明申请
    Protein tyrosine kinase inhibitors 有权
    蛋白酪氨酸激酶抑制剂

    公开(公告)号：US20060111371A1

    公开(公告)日：2006-05-25

    申请号：US10531107

    申请日：2003-10-09

    申请人： Wayne Danter ,  George Ma ,  Natalie Lazarowych ,  Stephen Houldsworth ,  Martyn Brown ,  Ghenadie Rusu ,  Jianhua Zhong

    发明人： Wayne Danter ,  George Ma ,  Natalie Lazarowych ,  Stephen Houldsworth ,  Martyn Brown ,  Ghenadie Rusu ,  Jianhua Zhong

    IPC分类号： A61K31/506

    CPC分类号： C07D401/14 ,  A61K31/506

    摘要： The present invention relates to uses of the compounds of Formula I as well as pharmaceutically acceptable salts and stereoisomers thereof in methods to treat a variety of tumors in mammals involving abnormal tyrosine kinase signalling, the compounds represented as: wherein R1 and R2 are independently selected from the group consisting of H; alkyl; alkenyl; alkynyl; halogen; aryl; heteroaryl containing N, O, or S; the aryl and heteroaryl may be further substituted with halogen, an alkyl, alkenyl, and alkynyl; NZ1Z2, wherein Z1 and Z2 are independently selected from the group consisting of H and alkyl; and (CO)Y wherein Y is selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, heteroaryl containing N, O, or S, and the aryl and heteroaryl may be further substituted with halogen, alkyl, alkenyl, and alkynyl; with the proviso that when R1 is hydrogen, R2 is a group other than hydrogen.

    摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和立体异构体在治疗涉及异常酪氨酸激酶信号传导的哺乳动物中的各种肿瘤的方法中的用途，所述化合物表示为：其中R 1， R 2和R 2独立地选自H; 烷基; 烯基; 炔基; 卤素; 芳基; 含有N，O或S的杂芳基; 芳基和杂芳基可以进一步被卤素，烷基，烯基和炔基取代; NZ 1 Z 2其中Z 1和Z 2独立地选自H和烷基 ; 和（CO）Y，其中Y选自H，烷基，烯基，炔基，芳基，含有N，O或S的杂芳基，芳基和杂芳基可以进一步被卤素，烷基，烯基和 炔基; 条件是当R 1是氢时，R 2是除氢之外的基团。

    Protein tyrosine kinase inhibitors
    5.
    发明授权
    Protein tyrosine kinase inhibitors 有权
    蛋白酪氨酸激酶抑制剂

    公开(公告)号：US07629347B2

    公开(公告)日：2009-12-08

    申请号：US10531107

    申请日：2003-10-09

    申请人： Wayne R. Danter ,  George Ma ,  Natalie Lazarowych ,  Stephen Houldsworth ,  Martyn Brown ,  Ghenadie Rusu ,  Jianhua Zhong

    发明人： Wayne R. Danter ,  George Ma ,  Natalie Lazarowych ,  Stephen Houldsworth ,  Martyn Brown ,  Ghenadie Rusu ,  Jianhua Zhong

    IPC分类号： C07D401/14 ,  A61K31/506

    CPC分类号： C07D401/14 ,  A61K31/506

    摘要： The present invention relates to uses of the compounds of Formula I as well as pharmaceutically acceptable salts and stereoisomers thereof in methods to treat a variety of tumors in mammals involving abnormal tyrosine kinase signaling, the compounds represented as: wherein R1 and R2 are independently selected from the group consisting of H; alkyl; alkenyl; alkynyl; halogen; aryl; heteroaryl containing N, O, or S; the aryl and heteroaryl may be further substituted with halogen, an alkyl, alkenyl, and alkynyl; NZ1Z2, wherein Z1 and Z2 are independently selected from the group consisting of H and alkyl; and (CO)Y wherein Y is selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, heteroaryl containing N, O, or S, and the aryl and heteroaryl may be further substituted with halogen, alkyl, alkenyl, and alkynyl; with the proviso that when R1 is hydrogen, R2 is a group other than hydrogen.

    摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和立体异构体在治疗涉及异常酪氨酸激酶信号传导的哺乳动物中的各种肿瘤的方法中的用途，所述化合物表示为：其中R1和R2独立地选自 由H组成的组; 烷基; 烯基; 炔基; 卤素; 芳基; 含有N，O或S的杂芳基; 芳基和杂芳基可以进一步被卤素，烷基，烯基和炔基取代; NZ1Z2，其中Z1和Z2独立地选自H和烷基; 和（CO）Y，其中Y选自H，烷基，烯基，炔基，芳基，含有N，O或S的杂芳基，芳基和杂芳基可以进一步被卤素，烷基，烯基和 炔基; 条件是当R 1是氢时，R 2是不同于氢的基团。