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公开(公告)号：US20230094580A1
公开(公告)日：2023-03-30
申请号：US17930042
申请日：2022-09-06
发明人： Haipeng Liu , Chunsong Yu
IPC分类号： A61K39/39 , A61K47/54 , C12N15/117
摘要： Amphiphilic oligonucleotide conjugates that enhance adjuvant function are disclosed. The conjugates typically include: a lipophilic component, and conjugated thereto (directly or indirectly) an immunomodulating oligonucleotide that, if it were not conjugated to the lipophilic component, would suppress TLR7 and/or TLR8 stimulation. In the presence of albumin, these conjugates significantly enhance adjuvant function, in particular the function of TLR7/8-mediated adjuvants such as an imidazoquinolinamine. The conjugates can be administered, along with an adjuvant compound, to a subject in order to cause and/or enhance an immune response (for instance, to an infectious agent or a cancer antigen) in the subject.
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公开(公告)号：US20200268879A1
公开(公告)日：2020-08-27
申请号：US16795953
申请日：2020-02-20
发明人： Haipeng Liu , Chunsong Yu
IPC分类号： A61K39/39 , A61K47/54 , C12N15/117
摘要： Amphiphilic oligonucleotide conjugates that enhance adjuvant function are disclosed. The conjugates typically include: a lipophilic component, and conjugated thereto (directly or indirectly) an immunomodulating oligonucleotide that, if it were not conjugated to the lipophilic component, would suppress TLR7 and/or TLR8 stimulation. In the presence of albumin, these conjugates significantly enhance adjuvant function, in particular the function of TLR7/8-mediated adjuvants such as an imidazoquinolinamine. The conjugates can be administered, along with an adjuvant compound, to a subject in order to cause and/or enhance an immune response (for instance, to an infectious agent or a cancer antigen) in the subject.
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公开(公告)号：US11504425B2
公开(公告)日：2022-11-22
申请号：US16795953
申请日：2020-02-20
发明人： Haipeng Liu , Chunsong Yu
IPC分类号： C07H21/04 , A61K39/39 , A61K47/54 , C12N15/117 , A61K39/00
摘要： Amphiphilic oligonucleotide conjugates that enhance adjuvant function are disclosed. The conjugates typically include: a lipophilic component, and conjugated thereto (directly or indirectly) an immunomodulating oligonucleotide that, if it were not conjugated to the lipophilic component, would suppress TLR7 and/or TLR8 stimulation. In the presence of albumin, these conjugates significantly enhance adjuvant function, in particular the function of TLR7/8-mediated adjuvants such as an imidazoquinolinamine. The conjugates can be administered, along with an adjuvant compound, to a subject in order to cause and/or enhance an immune response (for instance, to an infectious agent or a cancer antigen) in the subject.
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