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8 条记录 (耗时 0.024 秒)

    STABLE PHARMACEUTICAL COMPOSITION OF FREEZE-DRIED TETRODOTOXIN POWDER
    2.
    发明申请
    STABLE PHARMACEUTICAL COMPOSITION OF FREEZE-DRIED TETRODOTOXIN POWDER 有权
    冷冻干燥四酮酮粉末的稳定的药物组合物

    公开(公告)号：US20120264767A1

    公开(公告)日：2012-10-18

    申请号：US13533907

    申请日：2012-06-26

    申请人： Weiyang Lin ,  Xiao Zhang ,  Xiaoyan Huang

    发明人： Weiyang Lin ,  Xiao Zhang ,  Xiaoyan Huang

    IPC分类号： A61K31/519

    CPC分类号： A61K9/19 ,  A61K31/529 ,  A61K31/70 ,  A61K2300/00

    摘要： This invention relates to a stable pharmaceutical composition of freeze-dried tetrodotoxin powder which contains trace amount of tetrodotoxin, substances which can stabilizes tetrodotoxin, including disaccharide(s) or polyglucose(s) or analogues thereof and solvent(s), and solvents which can help tetrodotoxin dissolve.

    摘要翻译： 本发明涉及含有微量河豚毒素的稳定的冻干河豚毒素粉末的稳定药物组合物，能够稳定河豚毒素的物质，包括其二糖或多葡萄糖或其类似物和溶剂， 帮助河豚毒素溶解。

    Stable pharmaceutical composition of freeze-dried tetrodotoxin powder
    4.
    发明授权
    Stable pharmaceutical composition of freeze-dried tetrodotoxin powder 有权
    稳定的冻干河豚毒素药物组合物

    公开(公告)号：US08124608B2

    公开(公告)日：2012-02-28

    申请号：US10890279

    申请日：2004-07-14

    申请人： Xiao Zhang ,  Xiaoyan Huang ,  Weiyang Lin

    发明人： Xiao Zhang ,  Xiaoyan Huang ,  Weiyang Lin

    IPC分类号： A61K31/519

    CPC分类号： A61K9/19 ,  A61K31/529 ,  A61K31/70 ,  A61K2300/00

    摘要： This invention relates to a stable pharmaceutical composition of freeze-dried tetrodotoxin powder which contains trace amount of tetrodotoxin, substances which can stabilizes tetrodotoxin, including disaccharide(s) or polyglucose(s) or analogues thereof and solvent(s), and solvents which can help tetrodotoxin dissolve.

    摘要翻译： 本发明涉及含有微量河豚毒素的稳定的冻干河豚毒素粉末的稳定药物组合物，能够稳定河豚毒素的物质，包括其二糖或多葡萄糖或其类似物和溶剂， 帮助河豚毒素溶解。

    Sodium channel blocking compounds tetrodotoxin galactopyranosides
    6.
    发明授权
    Sodium channel blocking compounds tetrodotoxin galactopyranosides 有权
    钠通道阻断化合物河豚毒素吡喃半乳糖苷

    公开(公告)号：US08486901B2

    公开(公告)日：2013-07-16

    申请号：US13258529

    申请日：2010-03-26

    申请人： Weiyang Lin

    发明人： Weiyang Lin

    IPC分类号： A01N43/04 ,  A01N43/58 ,  A61K31/70 ,  A61K31/50 ,  C07H17/02 ,  C07D491/00

    CPC分类号： C07H15/26 ,  A61K31/7042

    摘要： Novel sodium channel blocking compounds tetrodotoxm galactopyranosides of formula I were isolated and purified by HPLC and identified further through IR, NMR, GC, and MS. The compounds have a galactopyranosyl moiety attached to C11 of tetrodotoxin and retain the analgesic activity of the latter. Pharmaceutical compositions and medical uses thereof are further disclosed.

    摘要翻译： 通过HPLC分离和纯化新型钠通道阻断化合物，其中式I的tetrodotoxm吡喃半乳糖苷通过IR，NMR，GC和MS进一步鉴定。 该化合物具有连接到河豚毒素C11的半乳糖基糖基部分并保留后者的止痛活性。 进一步公开了药物组合物及其医疗用途。

    Novel Sodium Channel Blocking Compounds Tetrodotoxin Galactopyranosides
    7.
    发明申请
    Novel Sodium Channel Blocking Compounds Tetrodotoxin Galactopyranosides 有权
    新型钠通道阻断化合物河豚毒素半乳糖苷

    公开(公告)号：US20120101054A1

    公开(公告)日：2012-04-26

    申请号：US13258529

    申请日：2010-03-26

    申请人： Weiyang Lin

    发明人： Weiyang Lin

    IPC分类号： A61K31/7064 ,  A61P29/00 ,  C07H15/26

    CPC分类号： C07H15/26 ,  A61K31/7042

    摘要： Novel sodium channel blocking compounds tetrodotoxm galactopyranosides of formula I were isolated and purified by HPLC and identified further through IR, NMR, GC, and MS. The compounds have a galactopyranosyl moiety attached to C11 of tetrodotoxin and retain the analgesic activity of the latter. Pharmaceutical compositions and medical uses thereof are further disclosed.

    摘要翻译： 通过HPLC分离和纯化新型钠通道阻断化合物，其中式I的tetrodotoxm吡喃半乳糖苷通过IR，NMR，GC和MS进一步鉴定。 该化合物具有连接到河豚毒素C11的半乳糖基糖基部分并保留后者的止痛活性。 进一步公开了药物组合物及其医疗用途。