公开(公告)号：US20040210048A1

公开(公告)日：2004-10-21

申请号：US10812156

申请日：2004-03-29

Applicant: WellSpring Pharmaceutical Corporation

Inventor： Robert Vukovich ,  Benjamin Levinson ,  George S. Drummond ,  Robert Caroselli ,  Kazimierz G. Antczak ,  Christopher Boucher ,  Richard Mortimer ,  Danny Levin ,  Keith A. Cooke

IPC: C07D487/22 ,  C07F015/02

CPC classification number: C07D487/22 ,  C07F7/003 ,  C07F15/025

Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.

Abstract translation: 描述了制备金属中卟啉卤化物的方法。 金属中卟啉卤化物可以通过形成新的中卟啉IX中间体化合物形成，然后通过金属插入将中卟啉IX中间体转化成金属中卟啉卤化物。 新型中间体化合物可以通过氢氧化锂在酸中的催化氢化和随后的回收形成。