公开(公告)号：US20070134277A1

公开(公告)日：2007-06-14

申请号：US11297639

申请日：2005-12-09

申请人： Wen Chen ,  Michael Shannon ,  Vimonrat Umprain ,  Whe-Yong Lo ,  Karl Weinrich

发明人： Wen Chen ,  Michael Shannon ,  Vimonrat Umprain ,  Whe-Yong Lo ,  Karl Weinrich

IPC分类号： A61K9/00 ,  A61K31/198

CPC分类号： A61K45/06 ,  A61K31/095 ,  A61K31/195 ,  A61K2300/00

摘要： The pharmaceutical formulations of the invention for masking the odor from the sulfur-containing active agent comprise at least one sulfur-containing active agent, an effective amount of at least one flavoring agent. Any flavoring agent or combinations of flavoring agents may be used in the pharmaceutical formulation of the invention. The flavoring agent may be natural flavors, natural fruit flavors, artificial flavors, and mixtures thereof. The pharmaceutical formulation may contain an artificial sweetener, a natural sweetener or mixtures thereof. The pharmaceutical formulations are provided in liquid dosage form or a dry powder dosage form for reconstitution in water. Stabilizer added as one of expicients can extend the stability of the pharmaceutical formulation liquid dosage form for a period of at least 30 days when the formulation is stored below room temperature. The pharmaceutical formulations of the invention are palatable and particularly useful for the administration of sulfur-containing drugs to very small children that are in need of such medications. Methods of forming a liquid dosage form of pharmaceutical formulation by adding water to the dry powder form, methods to prepare an odor-masking pharmaceutical formulation and methods for treating lead poisoning or Wilson's disease using the odor-masking pharmaceutical formulation are also provided.

摘要翻译： 用于掩蔽来自含硫活性剂的气味的本发明的药物制剂包含至少一种含硫活性剂，有效量的至少一种调味剂。 任何调味剂或调味剂的组合可用于本发明的药物制剂中。 调味剂可以是天然香料，天然水果香料，人造香料及其混合物。 药物制剂可以含有人造甜味剂，天然甜味剂或其混合物。 药物制剂以液体剂型或干粉剂型提供，用于在水中重构。 作为顾客之一添加的稳定剂可以将制剂储存在室温以下时将药物制剂液体剂型的稳定性延长至少30天。 本发明的药物制剂是可口的，并且特别可用于向需要这种药物的非常小的儿童施用含硫药物。 还提供了通过向干粉形式中加入水形成药物制剂的液体剂型的方法，制备防气味药物制剂的方法和使用该气味掩蔽药物制剂治疗铅中毒或威尔逊病的方法。

公开(公告)号：US20050191245A1

公开(公告)日：2005-09-01

申请号：US10789965

申请日：2004-02-27

申请人： Christopher Adams ,  Timothy Maher ,  Karl Weinrich

发明人： Christopher Adams ,  Timothy Maher ,  Karl Weinrich

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61L9/04

CPC分类号： A61K9/0043

摘要： Pharmaceutical compositions useful for the treatment of cardiovascular disorders such as hypertension are described. These compositions are formulated for nasal administration and comprise a therapeutically effective amount of a calcium channel blocker, optionally a pharmaceutically acceptable carrier that is suitable for nasal administration, and one or more optional members selected from excipients and additional pharmaceutically active agents.

摘要翻译： 描述了可用于治疗心血管疾病如高血压的药物组合物。 这些组合物被配制用于鼻腔给药，并且包含治疗有效量的钙通道阻滞剂，任选的适于鼻内给药的药学上可接受的载体，以及一种或多种选自赋形剂和另外的药物活性剂的任选成分。