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1.发明授权Benzothiepine 1, 1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07019023B2
公开(公告)日：2006-03-28
申请号：US10606771
申请日：2003-06-27
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K31/38
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 取代的式I的苯并噻吩1,1-二氧化物衍生物：其中R 1，R 2，R 3，R 4， Z和Z具有所示的含义，并描述了它们的生理上可耐受的盐和生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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2.发明授权Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06441022B1
公开(公告)日：2002-08-27
申请号：US09773772
申请日：2001-02-02
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K3138
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 描述式I的取代苯并噻吩1,1-二氧化物衍生物：其中R1，R2，R3，R4，R5和Z具有所示含义，并描述了其生理上可耐受的盐和生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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3.发明授权Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06221897B1
公开(公告)日：2001-04-24
申请号：US09398315
申请日：1999-09-20
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K3138
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 描述式I的取代苯并噻吩1,1-二氧化物衍生物：其中R1，R2，R3，R4，R5和Z具有所示含义，并描述了其生理上可耐受的盐和生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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4.发明授权Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06642269B2
公开(公告)日：2003-11-04
申请号：US10201050
申请日：2002-07-24
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K3138
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 取代的式I的苯并噻吩1,1-二氧化物衍生物：其中R 1，R 2，R 3，R 4，R 5和Z具有所示的含义，并且其生理上可耐受的盐 和生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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5.发明授权Benzo(b)thiepine-1,1-dioxide derivatives, a method for the production thereof, medicaments containing these compounds, and their use 有权苯并（b）硫嘌呤-1,1-二氧化物衍生物，其制备方法，含有这些化合物的药物及其用途公开(公告)号：US06387944B1
公开(公告)日：2002-05-14
申请号：US09719047
申请日：2000-12-07
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K3138
CPC分类号： C07D337/08 , A61K38/00 , C07K5/06086 , C08G65/329 , Y02P20/55
摘要： The invention relates to substituted benzo(b)thiepine-1,1-dioxide derivatives and to the acid addition salts thereof. The invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5 and Z have the cited descriptions, to the physiologically compatible salts, to physiologically functional derivatives, and to a method for the production thereof. The compounds are suited, for example, as hypolipidemic agents.
摘要翻译： 本发明涉及取代的苯并（b）硫脲-1,1-二氧化物衍生物及其酸加成盐。 本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4，R 5和Z具有生理上相容的盐，生理功能衍生物，以及其生产方法。 该化合物适合于例如降血脂药。
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6.发明授权Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use 失效具有改善的生理特性的二苯基氮杂环丁酮，其制备方法，包含该化合物的药物及其用途公开(公告)号：US07772429B2
公开(公告)日：2010-08-10
申请号：US11690993
申请日：2007-03-26
申请人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
发明人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
IPC分类号： C07C229/08 , C07C229/12
CPC分类号： C07C233/18 , C07D205/08
摘要： The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
摘要翻译： 本发明涉及式1的化合物及其生理上可接受的盐。 该化合物例如可用作降血脂药物。
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7.发明授权Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof 有权噻吩糖苷衍生物，制备方法，包含这些化合物的药物及其用途公开(公告)号：US07666848B2
公开(公告)日：2010-02-23
申请号：US11464338
申请日：2006-08-14
申请人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
发明人： Heiner Glombik , Wendelin Frick , Hubert Heuer , Werner Kramer , Harm Brummerhop , Oliver Plettenburg
CPC分类号： A61K45/06 , A61K31/7042 , C07H17/00 , A61K2300/00
摘要： Novel thiophene glycoside derivatives of the formula I in which the radicals have the stated meanings, and the physiologically tolerated salts thereof and processes for their preparation are disclosed. The compounds are suitable, for example, as antidiabetics.
摘要翻译： 公开了具有所述含义的式I的新型噻吩糖苷衍生物及其生理学上可耐受的盐及其制备方法。 该化合物例如适合作为抗糖尿病药。
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8.发明申请NOVEL 1,4-BENZOTHIEPIN-1, 1-DIOXIDE DERIVATIVES WITH IMPROVED PROPERTIES METHOD FOR PRODUCING THE SAME, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF 有权具有改进性质的新颖的1,4-苯并二氢吡喃-1,1-二氧化物衍生物，其制备方法，含有化合物的药物及其用途公开(公告)号：US20100035834A1
公开(公告)日：2010-02-11
申请号：US12465883
申请日：2009-05-14
申请人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
CPC分类号： C07H5/06 , C07D409/12
摘要： This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives with improved properties, method for producing the same, drugs containing said compounds and use thereof.
摘要翻译： 本发明涉及具有改进性质的新型1,4-苯并硫代-1,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途。
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9.发明授权Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use 有权环取代的二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07176194B2
公开(公告)日：2007-02-13
申请号：US10463807
申请日：2003-06-18
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： C07D205/08 , C07D227/00 , A61K31/397 , A61P3/06 , A61P9/10
CPC分类号： C07D403/12 , C07D205/08 , C07D453/02 , C07D487/08 , Y10S930/28
摘要： One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
摘要翻译： 本发明的一个实施方案涉及式I化合物，其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义。 本发明的其它实施方案涉及式I化合物的生理上可接受的盐，其制备方法和包含这些化合物的药物。 本发明的化合物适合用作例如降血脂药。
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10.发明授权Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use 有权酸基取代的二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07176193B2
公开(公告)日：2007-02-13
申请号：US10463388
申请日：2003-06-18
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： C07D205/08 , C07D227/00 , A61K31/397 , A61P3/06 , A61P9/10
CPC分类号： C07D205/08
摘要： One embodiment of the invention relates to compounds of the formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula 1, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
摘要翻译： 本发明的一个实施方案涉及式I化合物：其中R1，R2，R3，R4，R5和R6具有说明书中给出的含义。 本发明的其它实施方案涉及式1化合物的生理上可接受的盐，其制备方法和包含这些化合物的药物。 本发明的化合物适合用作例如降血脂药。
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