公开(公告)号：US07626046B2

公开(公告)日：2009-12-01

申请号：US10494005

申请日：2002-10-23

申请人： Werner Bonrath ,  David Carl Burdick ,  Frank Schager ,  Dominik Thomas ,  Thomas Netscher

发明人： Werner Bonrath ,  David Carl Burdick ,  Frank Schager ,  Dominik Thomas ,  Thomas Netscher

IPC分类号： C07D311/72

CPC分类号： C07D311/72

摘要： A process for the manufacture of (all-rac)-α-tocopherol comprises submitting isolated, purified phytyltrimethylhydroquinone to acid catalysis, thereby promoting ring closure to (all-rac)-α-t-tocopherol. The process can be conducted in the absence or presence of an added solvent, and when a solvent or solvent mixture is used the solvent or at least one solvent component of the solvent mixture is preferably one with a dipole moment greater than 9×10−30 C-m (or 2.7D). The nature of the catalyst is immaterial, but the catalyst is preferably sulphuric acid, phosphoric acid, a polyperfluoroalkylenesulphonic acid, a “NH-acid”, a heteropoly acid, zinc chloride, boron trifluoride, aluminium trichloride, or a mixture of any f the aforementioned Brönsted acids with any of the aforementioned Lewis acids. The product of the process is the most active an industrially most important member of the vitamin E group.

摘要翻译： 制备（全消旋）-α-生育酚的方法包括将分离的纯化的植酰三甲基氢醌提交到酸催化，从而促进闭环（全 - 外）-α-生育酚。 该方法可以在不存在或存在添加的溶剂的情况下进行，并且当使用溶剂或溶剂混合物时，溶剂或溶剂混合物的至少一种溶剂组分优选为偶极矩大于9×10-30 Cm（ 或2.7D）。 催化剂的性质是不重要的，但是催化剂优选为硫酸，磷酸，多氟亚烷基磺酸，“NH-酸”，杂多酸，氯化锌，三氟化硼，三氯化铝，或任何f 上述布朗斯台德酸与任何上述路易斯酸。 该过程的产物是维生素E组中工业上最重要的成员中最活跃的产物。

公开(公告)号：US20050187393A1

公开(公告)日：2005-08-25

申请号：US10494005

申请日：2002-10-23

申请人： Werner Bonrath ,  David Burdick ,  Frank Schager ,  Dominik Thomas

发明人： Werner Bonrath ,  David Burdick ,  Frank Schager ,  Dominik Thomas

IPC分类号： C07B61/00 ,  C07D311/72 ,  C07D311/76

CPC分类号： C07D311/72

摘要： A process for the manufacture of (all-rac)-α-tocopherol comprises submitting isolated, purified phytyltrimethylhydroquinone to acid catalysis, thereby promoting ring closure to (all-rac)-α-t-tocopherol. The process can be conducted in the absence or presence of an added solvent, and when a solvent or solvent mixture is used the solvent or at least one solvent component of the solvent mixture is preferably one with a dipole moment greater than 9×10+C-m (or 2.7 D). The nature of the catalyst is immaterial, but the catalyst is preferably sulphuric acid, phosphoric acid, a polyperfluoroalkylenesulphonic acid, a “NH-acid”, a heteropoly acid, zinc chloride, boron trifluoride, aluminium trichloride, or a mixture of any f the aforementioned Brönsted acids with any of the aforementioned Lewis acids. The product of the process is the most active an industrially most important member of the vitamin E group.

摘要翻译： 制备（全消旋）-α-生育酚的方法包括将分离的纯化的植酰三甲基氢醌提交到酸催化，从而促进闭环（全 - 外）-α-生育酚。 该方法可以在不存在或存在加入的溶剂的情况下进行，并且当使用溶剂或溶剂混合物时，溶剂或溶剂混合物的至少一种溶剂组分优选为偶极矩大于9×10 -6 Cm（或2.7D）。 催化剂的性质是不重要的，但是催化剂优选为硫酸，磷酸，多氟亚烷基磺酸，“NH-酸”，杂多酸，氯化锌，三氟化硼，三氯化铝，或任何f 上述布朗斯台德酸与任何上述路易斯酸。 该过程的产物是维生素E组中工业上最重要的成员中最活跃的产物。