公开(公告)号：US4911707A

公开(公告)日：1990-03-27

申请号：US231633

申请日：1988-08-10

申请人： Werner Heiber ,  Robert Andriola ,  Paul Williams ,  Charles Ebert

发明人： Werner Heiber ,  Robert Andriola ,  Paul Williams ,  Charles Ebert

IPC分类号： A61K9/70

CPC分类号： A61K9/703 ,  A61K9/7084 ,  A61K9/7092

摘要： A transdermal drug delivery system which is manufactured in a pre-activated state for at least one of storage stability, manufacture safety, user safety, or control of release characteristic considerations and which is activated by a patient (or other person applying the system to the patient) just prior to or immediately after applying the system to the patient's skin is disclosed.

摘要翻译： 一种透皮药物递送系统，其以预激活状态制造，用于储存稳定性，制造安全性，用户安全性或释放特性考虑的控制中的至少一种，并且由患者（或其他人将该系统应用于 公开了在将系统应用于患者皮肤之前或之后的患者皮肤上。

公开(公告)号：US4917676A

公开(公告)日：1990-04-17

申请号：US251016

申请日：1988-09-27

申请人： Werner Heiber ,  Robert Andriola ,  Paul Williams ,  Charles Ebert

发明人： Werner Heiber ,  Robert Andriola ,  Paul Williams ,  Charles Ebert

IPC分类号： A61K9/70

CPC分类号： A61K9/703 ,  A61K9/7084 ,  A61K9/7092

摘要： A transdermal drug delivery system which is manufactured in a pre-activated state for at least one of storage stability, manufacture safety, user safety, or control of release characteristic considerations and which is activated by a patient (or other person applying the system to the patient) just prior to or immediately after applying the system to the patient's skin is disclosed.

摘要翻译： 一种透皮药物递送系统，其以预激活状态制造，用于储存稳定性，制造安全性，用户安全性或释放特性考虑的控制中的至少一种，并且由患者（或其他人将该系统应用于 公开了在将系统应用于患者皮肤之前或之后的患者皮肤上。

公开(公告)号：US5662925A

公开(公告)日：1997-09-02

申请号：US638440

申请日：1996-04-26

申请人： Charles D. Ebert ,  Werner Heiber ,  William R. Good ,  Srinivasan Venkateshwaran

发明人： Charles D. Ebert ,  Werner Heiber ,  William R. Good ,  Srinivasan Venkateshwaran

IPC分类号： A61K9/70 ,  A61L25/00

CPC分类号： A61K9/703 ,  A61K9/7084

摘要： A device for administering an active agent to the skin or mucosa of an individual comprising a laminated composite of an adhesive overlay, a backing layer underlying the central portion of the adhesive overlay, an active agent-permeable membrane, the backing layer and membrane defining a reservoir that contains a formulation of the active agent, a peel seal disc underlying the active agent-permeable membrane, a heat seal about the periphery of the peel seal disc, the active agent-permeable membrane and the backing layer and a removable release liner underlying the exposed overlay and peel seal disc. The adhesive layer is above and peripheral to the path of the active agent to the skin or mucosa and is protected from degradation by the components of the reservoir by a multiplicity of heat seals. The peel seal disc protects against release of the active agent-containing reservoir and the release liner protects the adhesive from exposure to the environment prior to use.

摘要翻译： 一种用于向个体的皮肤或粘膜施用活性剂的装置，其包括粘合剂覆盖物，粘合剂覆盖物的中心部分下方的背衬层，活性剂渗透膜，背衬层和膜的层压复合材料 储存器，其包含活性剂的制剂，活性剂渗透膜下面的剥离密封盘，围绕剥离密封盘的周边的热密封，活性剂可渗透膜和背衬层以及可移除的释放衬垫 暴露的覆盖层和剥离密封盘。 粘合剂层位于活性剂到皮肤或粘膜的路径之上和周边，并通过多种热封保护储存器的部件免于降解。 剥离密封盘防止含活性剂的储存器的释放，并且释放衬垫在使用之前保护粘合剂免于暴露于环境中。

公开(公告)号：US5626866A

公开(公告)日：1997-05-06

申请号：US544110

申请日：1995-10-17

申请人： Charles D. Ebert ,  Srinivasan Venkateshwaran ,  Werner Heiber ,  Suresh Borsadia

发明人： Charles D. Ebert ,  Srinivasan Venkateshwaran ,  Werner Heiber ,  Suresh Borsadia

IPC分类号： A61K9/70 ,  A61K31/465 ,  A61F13/00 ,  A61F13/02

CPC分类号： A61K9/703 ,  A61K9/7061

摘要： A method for making a transdermal drug delivery device for heat sensitive and volatile drugs is disclosed. The device contains a drug-containing adhesive composite layer having an impermeable backing material laminated to the distal surface thereof and a proximal peelable impermeable backing material adapted for removal for administering a drug to the skin or mucosa laminated to the proximal surface thereof. The method comprising the steps of providing first and second adhesive laminates each comprising a drug permeable adhesive layer having laminated to one surface one of said backing materials and having the opposing surface exposed. The drug, in gelled form and optionally containing additives such as enhancers and preservatives, is extruded onto at least one exposed surface of the first or second adhesive laminate followed by laminating together the exposed surfaces of the first and second adhesive laminate such that the adhesive layers and gelled drug are combined to form the drug-containing adhesive composite layer having the distal and proximal surfaces covered by the respective backing materials. The adhesives used in making up the laminates may be the same or different provided the drug is compatible with the adhesive. The process is particularly adaptable to the formulation of nicotine-containing patches. Drug delivery devices made according to the disclosed method and a method of using these drug delivery devices are also described.

摘要翻译： 公开了制备用于热敏和挥发性药物的透皮药物递送装置的方法。 该装置含有含有药物的粘合剂复合层，其具有层压到其远端表面的不可渗透的背衬材料和适于去除的药物的近侧可剥离的不渗透背衬材料，以将药物施用于层压到其近侧表面的皮肤或粘膜。 该方法包括以下步骤：提供第一和第二粘合剂层压体，每个粘合层压板包括药物可渗透的粘合剂层，该粘合剂层层压到所述背衬材料的一个表面并且具有暴露的相对表面。 将胶体形式的药物和任选地含有添加剂如增强剂和防腐剂的药物挤压到第一或第二粘合层压体的至少一个暴露表面上，然后将第一和第二粘合层压体的暴露表面层压在一起，使得粘合剂层 并且凝胶化药物组合以形成具有由各个背衬材料覆盖的远侧和近侧表面的含药物的粘合剂复合材料层。 用于组合层压体的粘合剂可以相同或不同，只要药物与粘合剂相容即可。 该方法特别适用于含尼古丁的贴剂的制剂。 还描述了根据所公开的方法制备的药物递送装置和使用这些药物递送装置的方法。

公开(公告)号：US5152997A

公开(公告)日：1992-10-06

申请号：US652127

申请日：1991-02-07

申请人： Charles D. Ebert ,  Dinesh Patel ,  Werner Heiber

发明人： Charles D. Ebert ,  Dinesh Patel ,  Werner Heiber

IPC分类号： A61K9/06 ,  A61K9/70 ,  A61M37/00

CPC分类号： A61K9/7084

摘要： Testosterone is administered transdermally through nonscrotal skin in a manner that mimics in amount and profile the natural production of testosterone in young adult healthy males. The testosterone is administered to the skin from a matrix which contains testosterone at subsaturation concentration and a permeation enhancer.

摘要翻译： 睾丸激素通过非皮肤皮肤经皮穿透，其模拟量和形状在年轻成年健康男性中睾酮的天然产生。 将睾丸激素从含有不饱和浓度的睾酮的基质和渗透促进剂施用于皮肤。