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公开(公告)号：US08895592B2
公开(公告)日：2014-11-25
申请号：US12639173
申请日：2009-12-16
申请人： Jennifer M. Frost , Steven P. Latshaw , Michael J. Dart , William A. Carroll , Arturo Perez-Medrano , Teodozyj Kolasa , Meena V. Patel , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Xueqing Wang , Bo Liu
发明人： Jennifer M. Frost , Steven P. Latshaw , Michael J. Dart , William A. Carroll , Arturo Perez-Medrano , Teodozyj Kolasa , Meena V. Patel , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Xueqing Wang , Bo Liu
IPC分类号： A61K31/426 , C07D277/08
CPC分类号： C07D417/12 , C07D277/46 , C07D513/04
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein L1, A1, R1g, z, R2, R3, and R4 are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中L1，A1，R1g，z，R2，R3和R4如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20100069348A1
公开(公告)日：2010-03-18
申请号：US12560893
申请日：2009-09-16
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
IPC分类号： A61K31/397 , C07D405/02 , A61K31/4155 , A61P29/00 , A61P35/00 , A61P37/00 , A61P25/00 , A61P3/04 , A61P11/00 , A61P3/10 , A61P9/00 , C07D417/02 , A61K31/454
CPC分类号： C07D405/12 , C07D231/40 , C07D285/135 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
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公开(公告)号：US08859596B2
公开(公告)日：2014-10-14
申请号：US12560893
申请日：2009-09-16
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
IPC分类号： A61K31/433 , C07D285/12 , C07D405/12 , C07D413/14 , C07D413/12 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D285/135 , C07D231/40
CPC分类号： C07D405/12 , C07D231/40 , C07D285/135 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中A1，A5，Rx，X4和z如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US08492371B2
公开(公告)日：2013-07-23
申请号：US12732421
申请日：2010-03-26
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Tongmei Li , Bo Liu , Sridhar Peddi , Xueqing Wang , Teodozyj Kolasa , Derek W. Nelson , Arturo Perez-Medrano
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Tongmei Li , Bo Liu , Sridhar Peddi , Xueqing Wang , Teodozyj Kolasa , Derek W. Nelson , Arturo Perez-Medrano
IPC分类号： A61K31/397 , A61K31/433 , A61K31/42 , A61K31/416 , A61K31/4155 , A61K31/422 , C07D205/02 , C07D285/12 , C07D261/02 , C07D231/10 , C07D231/54 , C07D263/02
CPC分类号： C07D417/06 , C07D405/06 , C07D413/06
摘要： Disclosed herein are compounds of formula (I) wherein Ring A and R1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.
摘要翻译： 本文公开了式（I）的化合物，其中环A和R 1如说明书中所定义。 还公开了包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。
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公开(公告)号：US08188135B2
公开(公告)日：2012-05-29
申请号：US12560897
申请日：2009-09-16
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
IPC分类号： A61K31/415 , C07D231/06
CPC分类号： C07D405/12 , C07D231/40 , C07D285/135 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中A1，A5，Rx，X4和z如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20100249129A1
公开(公告)日：2010-09-30
申请号：US12732421
申请日：2010-03-26
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Tongmei Li , Bo Liu , Sridhar Peddi , Xueqing Wang , Teodozyj Kolasa , Derek W. Nelson , Arturo Perez-Medrano
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Tongmei Li , Bo Liu , Sridhar Peddi , Xueqing Wang , Teodozyj Kolasa , Derek W. Nelson , Arturo Perez-Medrano
IPC分类号： A61K31/433 , C07D417/08 , C07D417/06 , C07D405/06 , A61K31/443 , C07D413/06 , A61K31/422 , A61K31/4025 , A61K31/403 , C07D405/14 , C07D413/14 , A61K31/5377 , A61P29/00 , A61P25/00 , A61P37/02 , A61P11/00 , A61P35/00 , A61P9/00
CPC分类号： C07D417/06 , C07D405/06 , C07D413/06
摘要： Disclosed herein are compounds of formula (I) wherein Ring A and R1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.
摘要翻译： 本文公开了式（I）的化合物，其中环A和R 1如说明书中所定义。 还公开了包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。
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公开(公告)号：US20100216760A1
公开(公告)日：2010-08-26
申请号：US12639173
申请日：2009-12-16
申请人： Jennifer M. Frost , Steven P. Latshaw , Michael J. Dart , William A. Carroll , Arturo Perez-Medrano , Teodozyj Kolasa , Meena V. Patel , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Xueqing Wang , Bo Liu
发明人： Jennifer M. Frost , Steven P. Latshaw , Michael J. Dart , William A. Carroll , Arturo Perez-Medrano , Teodozyj Kolasa , Meena V. Patel , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Xueqing Wang , Bo Liu
IPC分类号： A61K31/427 , C07D417/12 , C07D471/04 , A61K31/437 , A61P29/00
CPC分类号： C07D417/12 , C07D277/46 , C07D513/04
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein L1, A1, R1g, z, R2, R3, and R4 are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中L1，A1，R1g，z，R2，R3和R4如说明书中所定义。 还提出了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20100069349A1
公开(公告)日：2010-03-18
申请号：US12560897
申请日：2009-09-16
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Steven P. Latshaw , Teodozyj Kolasa , Tongmei Li , Sridhar Peddi , Bo Liu , Arturo Perez-Medrano , Meena Patel , Xueqing Wang , Derek W. Nelson
IPC分类号： A61K31/397 , C07D207/30 , C07D285/12 , A61K31/40 , A61P3/10 , A61P9/10 , A61P25/00
CPC分类号： C07D405/12 , C07D231/40 , C07D285/135 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中A1，A5，Rx，X4和z如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20090105306A1
公开(公告)日：2009-04-23
申请号：US12246808
申请日：2008-10-07
申请人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
IPC分类号： A61K31/433 , C07D417/02 , C07D285/12 , C07D405/02 , C07D413/02 , A61P29/00 , A61P9/00 , A61P35/00 , A61P37/00 , A61P25/00 , A61K31/443 , A61K31/422 , A61K31/4155
CPC分类号： C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14
摘要： The present invention relates compounds of formula (I) wherein A and R1 are as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.
摘要翻译： 本发明涉及式（I）的化合物，其中A和R 1如说明书中所定义，包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。
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公开(公告)号：US09193713B2
公开(公告)日：2015-11-24
申请号：US12246808
申请日：2008-10-07
申请人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
IPC分类号： C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14
CPC分类号： C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14
摘要： The present invention relates compounds of formula (I) wherein A and R1 are as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.
摘要翻译： 本发明涉及式（I）的化合物，其中A和R 1如说明书中所定义，包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。
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