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1.发明申请公开(公告)号：US20080153883A1
公开(公告)日：2008-06-26
申请号：US11954956
申请日：2007-12-12
IPC分类号： A61K31/4439 , A61K31/426 , C07D417/02 , C07D277/02 , A61P35/00 , A61P25/28
CPC分类号： C07D277/18 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention relates to thiazolidinylidene containing compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, and X are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及含有噻唑烷亚基的式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 6和X如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法 。
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公开(公告)号：US20100234345A1
公开(公告)日：2010-09-16
申请号：US12612504
申请日：2009-11-04
申请人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
IPC分类号： A61K31/397 , C07D275/03 , A61K31/425 , C07D275/04 , A61K31/428 , C07D413/02 , A61K31/5377 , C07D277/02 , A61K31/426 , C07D417/14 , A61K31/4439 , C07D513/02 , A61K31/437 , C07D215/00 , A61K31/4709 , C07D417/02 , A61K31/454 , A61K31/497 , A61P29/00 , A61P25/00 , A61P35/00 , A61P37/00 , A61P11/00 , A61P9/00
CPC分类号： C07D275/02 , C07D275/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10 , Y02P20/582
摘要： The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.
摘要翻译： 本申请涉及含有异噻唑基的式（I）化合物，其中R 1，R 2，R 3，R 4和L如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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3.发明申请公开(公告)号：US20100093814A1
公开(公告)日：2010-04-15
申请号：US12274105
申请日：2008-11-19
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/426 , C07D277/28 , A61P25/00
CPC分类号： C07D277/46 , C07D277/28 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , C07D513/08
摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a, Rx, and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药物盐，前体药物，前体药物或其组合的盐，其中R1，R2，R3，R4和L1在具体实施方案中定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。 本发明还涉及式（II）化合物或其药物盐，前药，前体药物或其组合的盐，其中R 1a，R 2a，R x和n如说明书中所定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。
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公开(公告)号：US20090105306A1
公开(公告)日：2009-04-23
申请号：US12246808
申请日：2008-10-07
申请人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
IPC分类号： A61K31/433 , C07D417/02 , C07D285/12 , C07D405/02 , C07D413/02 , A61P29/00 , A61P9/00 , A61P35/00 , A61P37/00 , A61P25/00 , A61K31/443 , A61K31/422 , A61K31/4155
CPC分类号： C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14
摘要： The present invention relates compounds of formula (I) wherein A and R1 are as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.
摘要翻译： 本发明涉及式（I）的化合物，其中A和R 1如说明书中所定义，包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。
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公开(公告)号：US20090023789A1
公开(公告)日：2009-01-22
申请号：US12100731
申请日：2008-04-10
申请人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
IPC分类号： A61K31/425 , C07D275/02 , A61P29/00 , A61P35/00 , A61P9/00 , A61P25/00
CPC分类号： A61K31/425 , A61K31/427 , A61K31/429 , A61K31/4436 , A61K31/4725 , A61K31/5377 , C07D275/02 , C07D275/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10 , Y02P20/582
摘要： The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本申请涉及含有异噻唑基的式（I）化合物，其中R 1，R 2，R 3，R 4和L如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US08835475B2
公开(公告)日：2014-09-16
申请号：US12967282
申请日：2010-12-14
申请人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
IPC分类号： A61K31/425 , A61K31/5377 , A61K31/4725 , A61K31/4436 , A61K31/429 , A61K31/427
CPC分类号： A61K31/425 , A61K31/427 , A61K31/429 , A61K31/4436 , A61K31/4725 , A61K31/5377 , C07D275/02 , C07D275/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10 , Y02P20/582
摘要： The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本申请涉及含有异噻唑基的式（I）化合物，其中R 1，R 2，R 3，R 4和L如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US08546583B2
公开(公告)日：2013-10-01
申请号：US11755434
申请日：2007-05-30
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/426 , A61K31/427 , C07D417/06 , C07D417/14 , C07D277/44
CPC分类号： C07D277/82 , C07D277/46 , C07D277/48 , C07D277/60 , C07D417/06 , C07D417/12 , C07D477/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药物盐，前体药物，前体药物或其组合的盐，其中R1，R2，R3，R4和L1在说明书中定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。 本发明还涉及式（II）化合物或其药物盐，前药，前体药物或其组合的盐，其中R 1a，R 2a和（R x）n如说明书中所定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。
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公开(公告)号：US07875639B2
公开(公告)日：2011-01-25
申请号：US11755884
申请日：2007-05-31
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , C07D498/04 , C07D493/04 , C07D417/06 , C07D277/46 , C07D277/60 , C07D277/82
CPC分类号： C07D277/46 , A61K31/429 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前体药物或其组合的盐，其中R1，R2，R3，R4和L2在说明书中定义，包含这些化合物的组合物， 以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US09193713B2
公开(公告)日：2015-11-24
申请号：US12246808
申请日：2008-10-07
申请人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
IPC分类号： C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14
CPC分类号： C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14
摘要： The present invention relates compounds of formula (I) wherein A and R1 are as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.
摘要翻译： 本发明涉及式（I）的化合物，其中A和R 1如说明书中所定义，包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。
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公开(公告)号：US09006275B2
公开(公告)日：2015-04-14
申请号：US12970480
申请日：2010-12-16
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/429 , C07D513/04 , C07D277/46 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08
CPC分类号： C07D277/46 , A61K31/429 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前体药物或其组合的盐，其中R1，R2，R3，R4和L2在说明书中定义，包含这些化合物的组合物， 以及使用这些化合物和组合物治疗病症和病症的方法。
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