-
公开(公告)号：US07977474B2
公开(公告)日：2011-07-12
申请号：US11571130
申请日：2005-06-22
IPC分类号： C07D487/22 , A61K31/40 , A61K31/44 , A61B5/055
CPC分类号： A61K31/409
摘要： The invention provides the use of a compound of Formula (I), or metallated derivative thereof, in the preparation of a medicament for killing or attenuating the growth of microorganisms by a method which does not comprise exposing the compound to a photodynamic therapy light source or a sonodynamic therapy ultrasound source Formula (I) wherein X1, X2, X3, X4, Yi, Y2, Y3, Y4 and Z have meanings given in the description. Preferably, the microorganisms are selected from the group consisting off bacteria, mycoplasmas, yeasts, fungi and viruses.
摘要翻译： 本发明提供式（I）化合物或其金属化衍生物在制备用于通过不包括将化合物暴露于光动力学治疗光源的方法杀死或减弱微生物生长的药物中的用途，或 其中X1，X2，X3，X4，Yi，Y2，Y3，Y4和Z具有在说明书中给出的含义的声动力学治疗超声波源（I）。 优选地，微生物选自细菌，支原体，酵母，真菌和病毒组成的组。
-
2.发明申请Process for the Preparation of Porphyrin Derivatives as Antimicrobial Agents by Photodynamic Therapy (Pdt) 审中-公开通过光动力疗法制备卟啉衍生物作为抗微生物剂的方法（Pdt）公开(公告)号：US20080281091A1
公开(公告)日：2008-11-13
申请号：US12158779
申请日：2006-12-22
申请人： Derek Brundish , William Love , William Rhys-Williams , Xiang Dong Feng , Frederic Naud , Hans Meier
发明人： Derek Brundish , William Love , William Rhys-Williams , Xiang Dong Feng , Frederic Naud , Hans Meier
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： There is provided a process for the preparation of 5,15-bis-[4-(3-trimethylammonio-propyloxy)-phenyl]-porphyrin dihalide, wherein the process comprises step (a) of providing 4-(3-bromopropyloxy)benzaldehyde, step (b) of providing dipyrrolmethane, step (c) of reacting the 4-(3-bromopropyloxy)benzaldehyde with the dipyrrol-methane, together with trifluoro acetic acid, in the presence of an oxidation reagent to produce 5,15-bis-[4-(3-bromo-propyloxy)-phenyl]-porphyrin which is purified by Soxhlet extraction from the adsorbed state on a bed of alumina under highly controlled conditions; and step (d) of reacting the 5,15-bis-[4-(3-bromo-propyloxy)-phenyl]-porphyrin with trimethylamine in the presence of dry dimethylformamide to produce 5,15-bis-[4-(3-trimethylammonio-propyl-oxy)-phenyl]-porphyrin dibromide. In a preferred embodiment, the process further comprises step (e) of passing the 5,15-bis-[4-(3-trimethylammonio-propyloxy)-phenyl]-porphyrin dibromide produced in step (d) through an anion exchanger to produce 5,15-bis-[4-(3-trimethylammonio-propyloxy)-phenyl]-porphyrin dichloride. There is provided a process for the preparation of 5,15-bis-(4-{3-[(3-dimethylamino-propyl)-dimethyl-ammonio]-propyloxy}-phenyl]-porphyrin dihalide.
摘要翻译： 提供了制备5,15-双 - [4-（3-三甲基铵 - 丙氧基） - 苯基] - 卟啉二卤化物的方法，其中该方法包括步骤（a）提供4-（3-溴丙氧基）苯甲醛 ，提供二吡咯甲烷的步骤（b），步骤（c）在氧化试剂存在下使4-（3-溴丙氧基）苯甲醛与二吡咯甲烷一起与三氟乙酸一起反应，生成5,15-双 - [4-（3-溴 - 丙氧基） - 苯基] - 卟啉，其在高度控制的条件下通过索氏提取从氧化铝床上的吸附状态提纯; 和步骤（d）使5,15-双 - [4-（3-溴 - 丙氧基） - 苯基] - 卟啉与三甲胺在无水二甲基甲酰胺存在下反应，生成5,15-双 - [4-（3 - 三甲基铵 - 丙基 - 氧基） - 苯基 - 卟啉二溴化物。 在优选的实施方案中，该方法还包括步骤（e）使步骤（d）中产生的5,15-双 - [4-（3-三甲基铵 - 丙氧基） - 苯基 - - 卟啉二溴化物通过阴离子交换剂以产生 5,15-双 - [4-（3-三甲基铵 - 丙氧基） - 苯基] - 卟啉二氯化物。 提供了制备5,15-双 - （4- {3 - [（3-二甲基氨基 - 丙基） - 二甲基 - 氨基] - 丙氧基} - 苯基] - 卟啉二卤化物的方法。
-
公开(公告)号：US07244841B2
公开(公告)日：2007-07-17
申请号：US10744863
申请日：2003-12-23
IPC分类号： C07B47/00 , C07D487/22
CPC分类号： C07D487/22
摘要： A compound of formula I: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description, and metallated forms of such compounds, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and methods of treatment of a medical condition for which a photodynamic agent is indicated are also disclosed. Sterilizing solutions comprising a compound of the invention, and the use thereof, are also disclosed.
摘要翻译： 式I的化合物：其中X 1，X 2，X 3，X 4，Y，SUB Y 1，Y 3，Y 3，Y 4和Z具有在说明书中给出的含义，并且这样的金属化形式 化合物，其可用于治疗其中指示光动力学化合物的医学病症。 还公开了治疗指示光动力剂的医疗状况的药物制剂和方法。 还公开了包含本发明化合物的灭菌溶液及其用途。
-
公开(公告)号：US20070281915A1
公开(公告)日：2007-12-06
申请号：US11562183
申请日：2006-11-21
IPC分类号： A61K31/555 , C07D487/22
CPC分类号： C07D487/22
摘要： A compound of formula I: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description, and metallated forms of such compounds, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and methods of treatment of a medical condition for which a photodynamic agent is indicated are also disclosed. Sterilising solutions comprising a compound of the invention, and the use thereof, are also disclosed.
摘要翻译： 式I的化合物：其中X 1，X 2，X 3，X 4，Y，SUB Y 1，Y 3，Y 3，Y 4和Z具有在说明书中给出的含义，并且这样的金属化形式 化合物，其可用于治疗其中指示光动力学化合物的医学病症。 还公开了治疗指示光动力剂的医疗状况的药物制剂和方法。 还公开了包含本发明化合物的灭菌溶液及其用途。
-
公开(公告)号：US20070167619A1
公开(公告)日：2007-07-19
申请号：US11571130
申请日：2005-01-21
IPC分类号： C07D487/22
CPC分类号： A61K31/409
摘要： The invention provides the use of a compound of Formula (I), or metallated derivative thereof, in the preparation of a medicament for killing or attenuating the growth of microorganisms by a method which does not comprise exposing the compound to a photodynamic therapy light source or a sonodynamic therapy ultrasound source Formula (I) wherein X1, X2, X3, X4, Yi, Y2, Y3, Y4 and Z have meanings given in the description. Preferably, the microorganisms are selected from the group consisting off bacteria, mycoplasmas, yeasts, fungi and viruses.
摘要翻译： 本发明提供式（I）化合物或其金属化衍生物在制备用于通过不包括将化合物暴露于光动力学治疗光源的方法杀死或减弱微生物生长的药物中的用途，或 超声源超声波分子式（I）其中X 1，X 2，X 3，X 4， Y 1，Y 2，Y 3，Y 4和Z具有说明书中给出的含义。 优选地，微生物选自细菌，支原体，酵母，真菌和病毒组成的组。
-
公开(公告)号：US08084602B2
公开(公告)日：2011-12-27
申请号：US11562183
申请日：2006-11-21
IPC分类号： C07D487/22 , C07B47/00
CPC分类号： C07D487/22
摘要： A compound of formula I: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description, and metallated forms of such compounds, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and methods of treatment of a medical condition for which a photodynamic agent is indicated are also disclosed. Sterilizing solutions comprising a compound of the invention, and the use thereof, are also disclosed.
摘要翻译： 式I的化合物：其中X 1，X 2，X 3，X 4，Y 1，Y 2，Y 3，Y 4和Z具有说明书中给出的含义，以及这些化合物的金属化形式，其可用于治疗其中 指示光动力学化合物。 还公开了治疗指示光动力剂的医疗状况的药物制剂和方法。 还公开了包含本发明化合物的灭菌溶液及其用途。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.025 秒)
