公开(公告)号：US20230000771A1

公开(公告)日：2023-01-05

申请号：US17840964

申请日：2022-06-15

Applicant: Wisconsin Alumni Research Foundation

Inventor： Seungpyo Hong ,  Allan Brasier ,  Weiping Tang

IPC: A61K9/107 ,  A61K47/10 ,  A61K47/34 ,  A61K47/69

Abstract: A self-assembled therapeutic dendron-micelle includes a first amphiphilic dendron-coil, a second amphiphilic dendron-coil, and optionally a third amphiphilic dendron-coil, and an encapsulated BRD4 ligand or BRD4 proteolysis targeting chimera. The first and optional third amphiphilic dendron-coils have a therapeutic peptide conjugated thereto. Also included are pharmaceutical compositions containing the dendron-micelles, methods of making the dendron-micelles, and therapeutic methods including administering the dendron-micelles to a subject in need thereof.