Patent search ap:("Wisconsin Alumni Research Foundation") AND inv:"Kyle Alexander Brown" Page 1

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发明申请
ACTIVATING APPENDAGES TO INDUCE POLYPHARMACOLOGY IN PEPTIDE HORMONE ANALOGUES, INCLUDING DUAL GLP-1R / GIP AGONISM 有权

公开(公告)号：US20250026782A1

公开(公告)日：2025-01-23

申请号：US18752309

申请日：2024-06-24

Applicant: Wisconsin Alumni Research Foundation

Inventor： Samuel Helmer Gellman , Rylie Kathleen Morris , Kyle Alexander Brown

IPC: C07K1/00 , A61K38/00 , C07K14/605

Abstract: Compounds, method of making the compounds, and methods of using the compounds to treat Type 2 diabetes and obesity in mammals, including humans. The compounds are dual GLP-1 receptor and GIP receptor agonists in which at least one side chain of a residue in GLP-1 and/or GIP is modified such that the modified GLP-1 and GIP are agonists of both GLP-1 receptor and GIP receptor.

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