公开(公告)号：US20250009918A1

公开(公告)日：2025-01-09

申请号：US18712655

申请日：2022-11-22

Applicant: Wisconsin Alumni Research Foundation

Inventor： Shaoqin Gong ,  Ying Zhang ,  Zachary Morris ,  Raghava N. Sriramaneni

IPC: A61K51/12 ,  A61K38/20 ,  A61K45/06 ,  A61K47/54 ,  A61K47/64 ,  A61K47/69 ,  A61K49/00 ,  A61K51/04 ,  A61N5/10 ,  A61P35/00

Abstract: The present technology provides nanoparticles comprising a positively charged polymer (e.g., polylysine) electrostatically bound to iron oxide nanoparticles and CpG oligodeoxy nucleotide. Further provided are compositions comprising same and methods of sensitizing tumor cells to radiation therapy, methods of stimulating antigen presenting cells, methods of enhancing stimulation of a type I interferon, and methods of treatment using said nanoparticles and compositions.