公开(公告)号：US5086173A

公开(公告)日：1992-02-04

申请号：US699067

申请日：1991-05-13

申请人： Wolfgang Tritschler ,  Heinz Steiner ,  Helmut Prestel ,  Rudolf Maul

发明人： Wolfgang Tritschler ,  Heinz Steiner ,  Helmut Prestel ,  Rudolf Maul

IPC分类号： C07D251/46 ,  C08K5/37

CPC分类号： C07D251/46

摘要： A process for the preparation of compounds of formula I ##STR1## wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen, C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.6 cycloalkyl or phenyl, and R.sub.3 and R.sub.4 are each independently of the other C.sub.1 -C.sub.18 alkyl, C.sub.5 -C.sub.6 cycloalkyl, phenyl, phenyl which is substituted by C.sub.1 -C.sub.6 alkyl and/or hydroxy, or phenyl-C.sub.1 -C.sub.4 alkyl. The process comprises reacting a compound of formula III ##STR2## with a nitrite in aqueous or aqueous/organic medium to a compound of formula II ##STR3## extracting said compound of formula II from the reaction solution with a solvent, hydrogenating said compound, without isolation, in the cited solvent and in the presence of a palladium catalyst, to the corresponding p-aminophenol, and reacting said aminophenol, without isolation, with cyanuric chloride and a compound of formula HSR.sub.3 or HSR.sub.4 or a mixture of compounds of formulae HSR.sub.3 and HSR.sub.4. The products are obtained in high yield and purity.

摘要翻译： 制备式I化合物的方法（I）其中R 1和R 2各自独立于其它的氢，C 1 -C 12烷基，C 5 -C 6环烷基或苯基，且R 3和R 4各自独立地为其它的C1- C 1 -C 6烷基，C 5 -C 6环烷基，苯基，被C 1 -C 6烷基和/或羟基取代的苯基或苯基-C 1 -C 4烷基。 该方法包括使式III化合物（III）与水性或水/有机介质中的亚硝酸盐反应到式II化合物（II），用溶剂从反应溶液中提取所述式II化合物 在所述溶剂中并在钯催化剂存在下，将所述化合物氢化为相应的对氨基苯酚，并将所述氨基苯酚与氰尿酰氯和式HSR3或HSR4的化合物或其混合物 的式HSR3和HSR4的化合物。 以高产率和纯度获得产品。