公开(公告)号：US20170299609A1

公开(公告)日：2017-10-19

申请号：US15490094

申请日：2017-04-18

Applicant: Wright State University

Inventor： Sherif Elbasiouny

IPC: G01N33/68 ,  A61K31/522 ,  A61K31/712 ,  C12N15/85

CPC classification number: C12N15/8509 ,  A61K31/428 ,  A61K31/506 ,  A61K31/519 ,  C12N2015/8527 ,  C12N2015/8536

Abstract: Methods for treating amyotrophic lateral sclerosis (ALS). The methods include administering to a subject in need thereof a therapeutically effective amount of at least one small conductance calcium-activated potassium (SK) channel activator or a pharmaceutically acceptable salt or solvate thereof. Pharmaceutical compositions for the treatment of ALS, including a therapeutically effective amount of at least one SK channel activator, or a pharmaceutically acceptable salt or solvate thereof, and at least one excipient, adjuvant, or pharmaceutically acceptable carrier.