公开(公告)号：US20180265578A1

公开(公告)日：2018-09-20

申请号：US15844526

申请日：2017-12-16

Applicant: Wyeth LLC

Inventor： Edward Roland LaVallie ,  Lisa Anne Collins-Racie ,  Christopher John Corcoran ,  Lioudmila Gennadievna Tchistiakova ,  John Adam Nowak ,  Riyez Karim ,  Xiang-Yang Tan ,  Kimberly Ann Marquette ,  Geertruida Machteld Veldman

IPC: C07K16/22 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  H05K999/00

Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

公开(公告)号：US20170145084A1

公开(公告)日：2017-05-25

申请号：US15230430

申请日：2016-08-07

Applicant: Wyeth LLC

Inventor： Edward Roland LaVallie ,  Lisa Anne Collins-Racie ,  Christopher John Corcoran ,  Lioudmila Gennadievna Tchistiakova ,  John Adam Nowak ,  Riyez Karim ,  Xiang-Yang Tan ,  Kimberly Ann Marquette ,  Geertruida Machteld Veldman

IPC: C07K16/22

CPC classification number: C07K16/22 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

公开(公告)号：US09850301B2

公开(公告)日：2017-12-26

申请号：US15230430

申请日：2016-08-07

Applicant: Wyeth LLC

Inventor： Edward Roland LaVallie ,  Lisa Anne Collins-Racie ,  Christopher John Corcoran ,  Lioudmila Gennadievna Tchistiakova ,  John Adam Nowak ,  Riyez Karim ,  Xiang-Yang Tan ,  Kimberly Ann Marquette ,  Geertruida Machteld Veldman

IPC: C12N1/21 ,  C12N1/11 ,  C12N1/13 ,  C12N1/19 ,  C12N5/10 ,  C12N5/16 ,  C12N15/11 ,  C12N15/13 ,  C12N15/63 ,  C07K16/22 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

公开(公告)号：US10189896B2

公开(公告)日：2019-01-29

申请号：US15844526

申请日：2017-12-16

Applicant: Wyeth LLC

Inventor： Edward Roland LaVallie ,  Lisa Anne Collins-Racie ,  Christopher John Corcoran ,  Lioudmila Gennadievna Tchistiakova ,  John Adam Nowak ,  Riyez Karim ,  Xiang-Yang Tan ,  Kimberly Ann Marquette ,  Geertruida Machteld Veldman

IPC: G01N33/53 ,  G01N33/50 ,  G01N33/48 ,  G01N33/543 ,  G01N33/563 ,  G01N33/58 ,  G01N33/68 ,  C07K16/22 ,  A61K39/395 ,  A61K39/00

Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.