公开(公告)号：US20140371203A1

公开(公告)日：2014-12-18

申请号：US14358722

申请日：2012-11-15

申请人： XENTION LIMITED

发明人： David Madge ,  Fiona Chan ,  Derek Edward John ,  Simon D. Edwards ,  Richard Blunt ,  Basil Hartzoulakis ,  Lindsay Brown

IPC分类号： C07D495/04

CPC分类号： C07D495/04 ,  A61K31/519 ,  C07D491/048

摘要： The present invention provides compounds of formula (I): (Formula (I); wherein A, R1, R2, R3I, V, X, and Z are defined herein, which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula (I) and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof.

摘要翻译： 本发明提供式（I）化合物：（式（I））其中A，R 1，R 2，R 3，V，X和Z如本文所定义，其为钾通道抑制剂。 式（I）化合物及其在治疗中的用途，特别是在治疗由Kir3.1和/或Kir3.4或其任何异源多肽介导的疾病或病症或需要抑制Kir3.1和/或Kir3 .4或其任何异源多聚体。

公开(公告)号：US20160152634A1

公开(公告)日：2016-06-02

申请号：US15016846

申请日：2016-02-05

申请人： XENTION LIMITED

发明人： David Madge ,  Fiona Chan ,  Derek Edward John ,  Simon D. Edwards ,  Richard Blunt ,  Basil Hartzoulakis ,  Lindsay Brown

IPC分类号： C07D495/04 ,  C07D491/048

CPC分类号： C07D495/04 ,  A61K31/519 ,  C07D491/048

摘要： The present invention provides compounds of formula (I): (Formula (I)); wherein A, R1, R2, R3I, V, X, and Z are defined herein, which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula (I) and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof.

摘要翻译： 本发明提供式（I）的化合物：（式（I））; 其中A，R1，R2，R3I，V，X和Z在本文中定义，其是钾通道抑制剂。 本发明还提供了包含式（I）化合物及其在治疗中的用途的药物组合物，特别是在治疗由Kir3.1和/或Kir3.4或其任何异源多聚体介导的或需要抑制的疾病或病症 的Kir3.1和/或Kir3.4或其任何异源多聚体。

公开(公告)号：US09290511B2

公开(公告)日：2016-03-22

申请号：US14358722

申请日：2012-11-15

申请人： XENTION LIMITED

发明人： David Madge ,  Fiona Chan ,  Derek Edward John ,  Simon D. Edwards ,  Richard Blunt ,  Basil Hartzoulakis ,  Lindsay Brown

IPC分类号： C07D495/04 ,  A61K31/519 ,  A61P9/06 ,  C07D491/048

CPC分类号： C07D495/04 ,  A61K31/519 ,  C07D491/048

摘要： The present invention provides compounds of formula (I): (Formula (I); wherein A, R1, R2, R3I, V, X, and Z are defined herein, which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula (I) and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof.

摘要翻译： 本发明提供式（I）化合物：（式（I））其中A，R 1，R 2，R 3，V，X和Z如本文所定义，其为钾通道抑制剂。 式（I）化合物及其在治疗中的用途，特别是在治疗由Kir3.1和/或Kir3.4或其任何异源多肽介导的疾病或病症或需要抑制Kir3.1和/或Kir3 .4或其任何异源多聚体。