公开(公告)号：US20040071332A1

公开(公告)日：2004-04-15

申请号：US10616366

申请日：2003-07-09

Applicant: XEROX CORPORATION

Inventor： Richard H. Bruce ,  Douglas N. Curry ,  Robert T. Krivacic ,  Huangpin B. Hsieh

IPC: G06K009/00

CPC classification number: B82Y20/00 ,  B82Y5/00 ,  B82Y10/00 ,  G01N15/1468 ,  G01N2015/0065

Abstract: In accordance with one aspect of the present application, an imager and method for detecting and locating rare cells in a sample is disclosed. An imager stage supports the sample. A fiber optic bundle has a proximate bundle end of first fiber ends arranged to define an input aperture viewing the sample on the translation stage. The fiber optic bundle further has a distal bundle end of second fiber ends arranged to define an output aperture shaped differently from the input aperture and disposed away from the imager stage. A scanning radiation source is arranged in fixed relative position to the input aperture. The scanning radiation source scans a radiation beam on the sample within a viewing area of the input aperture. The radiation beam interacts with the sample to produce a light signal that is reflected, scattered, transmitted, re-emitted, or otherwise collected and received by the input aperture and transmitted via the fiber optic bundle to the output aperture. The scanning radiation source rasters the radiation beam over a selected area of the sample. A photodetector is arranged to detect the light signal at the distal bundle end, and a processor processes the detected light signals.

Abstract translation: 根据本申请的一个方面，公开了一种用于检测和定位样品中的稀有细胞的成像器和方法。 成像器台支持样品。 光纤束具有布置成限定观察平移台上的样品的输入孔的第一光纤端的近端束端。 光纤束还具有设置成限定与输入孔不同的形状的输出孔并远离成像器台设置的第二纤维端的远端束端。 扫描辐射源被布置在与输入孔相对的固定相对位置。 扫描辐射源在输入孔的观察区域内扫描样品上的辐射束。 辐射束与样品相互作用以产生被信号反射，散射，透射，再发射或以其它方式收集和接收的光信号，并通过光纤束传输到输出孔。 扫描辐射源将辐射束照射在样品的选定区域上。 光检测器被设置为检测远端束端处的光信号，并且处理器处理检测到的光信号。