公开(公告)号：US20250057999A1

公开(公告)日：2025-02-20

申请号：US18893474

申请日：2024-09-23

Applicant: XIAMEN UNIVERSITY

Inventor： Zhide GUO ,  Xingxing CHENG ,  Xianzhong ZHANG ,  Hongwu LIU ,  Xueqi WANG

IPC: A61K51/08 ,  A61P35/00

Abstract: Provided is a glutamic acid (Glu)-urea compound and a preparation method and use thereof. The Glu-urea compound and the nuclide-targeted probe have excellent in vivo biological properties and show a high specific uptake in lesions with high expression of a prostate-specific membrane antigen (PSMA) protein. The compound and probe have a high target/non-target ratio, low non-specific background activity, and significantly-enhanced tumor uptake and retention time. The compound and probe are suitable for use in the nuclide therapy and imaging of tumors, and can also reduce unnecessary radiation damage to normal tissues and organs. The compound and probe can also overcome the shortcomings such as low target organ uptake and short retention time of small-molecule PSMA, and improve the effects of PSMA-targeted nuclide therapy and imaging, thus exhibiting a potential to be widely used in clinical applications.