公开(公告)号：US20240408075A1

公开(公告)日：2024-12-12

申请号：US18603554

申请日：2024-03-13

Applicant: Xenon Pharmaceuticals Inc.

Inventor： James Philip Johnson, JR.

IPC: A61K31/472 ,  A61K31/165 ,  A61K31/19 ,  A61K31/4015 ,  A61K31/41 ,  A61K31/4166 ,  A61P25/08

Abstract: In certain embodiments, the present disclosure is directed to methods and uses for treating seizure disorders in a human in need thereof, wherein the methods and uses comprise conjointly administering N44-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-2,6-dimethylphenyll-3,3-dimethylbutanamide (Compound A) and an antiseizure medication (ASM) to the human in amounts that are therapeutically effective when conjointly administered. The present disclosure is further directed to various improved methods of therapy and administration of Compound A.

公开(公告)号：US20240342156A1

公开(公告)日：2024-10-17

申请号：US18415139

申请日：2024-01-17

Applicant: Xenon Pharmaceuticals Inc.

Inventor： James Philip Johnson, JR. ,  Gregory N. Beatch

IPC: A61K31/472 ,  A61K9/00 ,  A61P23/00

CPC classification number: A61K31/472 ,  A61K9/0053 ,  A61P23/00

Abstract: In certain embodiments, the present disclosure is directed to methods for treating pain in a subject, such as a human, wherein the methods comprise orally administering a therapeutically effective amount of N-[4-(6-fluoro-3,4-dihydro-1H-isoquinolin-2-yl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide (Compound A), to the subject in need thereof. The present disclosure is further directed to various improved methods of therapy and administration of Compound A.

公开(公告)号：US20210171537A1

公开(公告)日：2021-06-10

申请号：US16805895

申请日：2020-03-02

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Christophe Andrez ,  David Earl Bogucki ,  Kristen Nicole Burford ,  Sultan Chowdhury ,  Charles Jay Cohen ,  Shannon Marie Decker ,  Christoph Martin Dehnhardt ,  Robert Joseph Devita ,  James Roy Empfield ,  Thilo Focken ,  Michael Edward Grimwood ,  Syed Abid Hasan ,  Qi Jia ,  James Philip Johnson, JR. ,  Michael Scott Wilson ,  Alla Yurevna Zenova

IPC: C07D491/107 ,  C07D493/10 ,  C07D237/20 ,  C07D213/76 ,  C07D239/69 ,  C07D261/16 ,  C07D263/50 ,  C07D275/03 ,  C07D277/52 ,  C07D285/08 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/10 ,  C07D417/14 ,  C07D451/06

Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

公开(公告)号：US20180162868A1

公开(公告)日：2018-06-14

申请号：US15600612

申请日：2017-05-19

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Christophe Andrez ,  David Earl Bogucki ,  Kristen Nicole Burford ,  Sultan Chowdhury ,  Charles Jay Cohen ,  Shannon Marie Decker ,  Christoph Martin Dehnhardt ,  Robert Joseph Devita ,  James Roy Empfield ,  Thilo Focken ,  Michael Edward Grimwood ,  Syed Abid Hasan ,  Qi Jia ,  James Philip Johnson, JR. ,  Michael Scott Wilson ,  Alla Yurevna Zenova

IPC: C07D491/107 ,  C07D277/52 ,  C07D417/12 ,  C07D213/76 ,  C07D285/08 ,  C07D401/12 ,  C07D403/12 ,  C07D275/03 ,  C07D239/69 ,  C07D261/16 ,  C07D413/12 ,  C07D263/50 ,  C07D487/10

Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

公开(公告)号：US20190194184A1

公开(公告)日：2019-06-27

申请号：US16289212

申请日：2019-02-28

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Christophe Andrez ,  Kristen Nicole Burford ,  Sultan Chowdhury ,  Charles Jay Cohen ,  Christoph Martin Dehnhardt ,  Robert Joseph Devita ,  James Roy Empfield ,  Thilo Focken ,  Michael Edward Grimwood ,  Syed Abid Hasan ,  James Philip Johnson, JR. ,  Alla Yurevna Zenova

IPC: C07D451/06 ,  C07D285/08 ,  C07D277/52 ,  C07D493/10 ,  C07D261/16 ,  C07D417/12 ,  C07D401/12 ,  C07D239/69 ,  C07D237/20 ,  C07D213/76 ,  C07D403/12 ,  C07D417/14 ,  C07D413/12

Abstract: This invention is directed to methods of preparing benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

公开(公告)号：US20170334902A1

公开(公告)日：2017-11-23

申请号：US15600490

申请日：2017-05-19

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Jean-Christophe Andrez ,  Kristen Nicole Burford ,  Sultan Chowdhury ,  Charles Jay Cohen ,  Christoph Martin Dehnhardt ,  Robert Joseph Devita ,  James Roy Empfield ,  Thilo Focken ,  Michael Edward Grimwood ,  Syed Abid Hasan ,  James Philip Johnson, JR. ,  Alla Yurevna Zenova

IPC: C07D451/06 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D451/06 ,  C07D213/76 ,  C07D237/20 ,  C07D239/69 ,  C07D261/16 ,  C07D277/52 ,  C07D285/08 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D493/10

Abstract: This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.