公开(公告)号：US10100060B2

公开(公告)日：2018-10-16

申请号：US15625173

申请日：2017-06-16

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Ronen Ben-David ,  Jian Chen ,  Michael A. Christie ,  Mina Gadelrab Dimitri ,  Graciela Noemi Gershon ,  Linli He ,  Nelson G. Landmesser ,  Daniel V. Levy ,  Orel Yosef Mizrahi ,  Partha S. Mudipalli ,  Harlan F. Reese ,  Joseph A. Sclafani ,  Yi Wang

IPC: C07D491/20 ,  C07D405/10 ,  C07D209/34 ,  B01J31/02

Abstract: This invention is directed to asymmetric synthesis of funapide, which is useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.