公开(公告)号：US10513526B2

公开(公告)日：2019-12-24

申请号：US16156718

申请日：2018-10-10

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Ronen Ben-David ,  Stephen Bierlmaier ,  Ralph Curtis Haltiwanger ,  Alexandr Jegorov ,  Raeann Ruiyun Wu ,  Mehran Yazdanian

IPC: C07D491/20 ,  A61K31/407

Abstract: The present invention provides solid state forms of certain spiro-oxindole compounds, such as funapide and the racemic mixture of funapide and its corresponding (R) enantiomer, pharmaceutical compositions comprising the solid state forms and processes for preparing the solid state forms and the pharmaceutical compositions.

公开(公告)号：US20190071449A1

公开(公告)日：2019-03-07

申请号：US16156718

申请日：2018-10-10

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Ronen Ben-David ,  Stephen Bierlmaier ,  Ralph Curtis Haltiwanger ,  Alexandr Jegorov ,  Raeann Ruiyun Wu ,  Mehran Yazdanian

IPC: C07D491/20 ,  A61K31/407

CPC classification number: C07D491/20 ,  A61K31/407 ,  C07B2200/13 ,  H05K999/99

Abstract: The present invention provides solid state forms of certain spiro-oxindole compounds, such as funapide and the racemic mixture of funapide and its corresponding (R) enantiomer, pharmaceutical compositions comprising the solid state forms and processes for preparing the solid state forms and the pharmaceutical compositions.

公开(公告)号：US10118932B2

公开(公告)日：2018-11-06

申请号：US15625724

申请日：2017-06-16

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Ronen Ben-David ,  Stephen Bierlmaier ,  Ralph Curtis Haltiwanger ,  Alexandr Jegorov ,  Raeann Ruiyun Wu ,  Mehran Yazdanian

IPC: C07D491/20 ,  A61K31/407

Abstract: The present invention provides solid state forms of certain spiro-oxindole compounds, such as funapide and the racemic mixture of funapide and its corresponding (R) enantiomer, pharmaceutical compositions comprising the solid state forms and processes for preparing the solid state forms and the pharmaceutical compositions.