公开(公告)号：US20230405023A1

公开(公告)日：2023-12-21

申请号：US18248663

申请日：2021-04-09

Applicant: Xenon Pharmaceuticals Inc.

Inventor： Gregory N. Beatch ,  Rostam Namdari

IPC: A61K31/635 ,  A61K31/4166

CPC classification number: A61K31/635 ,  A61K31/4166

Abstract: Provided are methods for treating diseases or conditions associated with Nav1.6 activity in a patient, comprising administering to said patient (S)-4((1-benzylpyrrolidin-3-yl)(methypamino)-2-fluoro-5-methyl-N(thiazol-4-yl)benzenesulfonamide or a pharmaceutically acceptable salt thereof, wherein the patient is also being administered a strong inducer of cytochrome P450 3A4 (CYP3A4).