公开(公告)号：US20080207758A1

公开(公告)日：2008-08-28

申请号：US11995363

申请日：2006-07-10

申请人： Xiaodong Cong

发明人： Xiaodong Cong

IPC分类号： A61K31/192 ,  C07C65/34 ,  A61P19/02 ,  A61P3/00 ,  A61P1/00

CPC分类号： C07C66/02 ,  A61K31/192 ,  A61K31/197 ,  A61K31/198 ,  A61K31/4965 ,  A61K2300/00

摘要： The conjugates of present invention are formed by the combination of rhein or their analogues with the organic bases or amino acids in molecular force between them. The methods for preparing the conjugates and their uses for manufacturing medicines in the treatment of diabetic nephrosis, recovery of gastrointestinal function and prevention of intestinal adhesion, as well as treatment of osteoarthritis, rheumatic arthritis and rheumatoid arthritis are also described. Rhein or their analogues as the left part of general formula (I) is selected from (1) the compounds of rhein or their analogues, in which one or two substituents of R2˜R3 and R6˜R7 are COOH at least two substituents of R1˜8 are —H; or (2) the rhein-containing extract derived from plants. In general formula (I), M represents nitrogen-containing organic bases or basic amino acids.

摘要翻译： 本发明的缀合物通过大分子蛋白或其类似物与它们之间的分子力与有机碱或氨基酸的组合形成。 还描述了制备缀合物的方法及其在治疗糖尿病肾病中的药物制备，胃肠功能恢复和肠粘连预防以及治疗骨关节炎，风湿性关节炎和类风湿性关节炎的用途。 大肠杆菌或其类似物作为通式（I）的左侧部分选自（1）大黄酸或其类似物的化合物，其中R 2〜R 3和R 6〜R 7的一个或两个取代基是COOH，至少两个R 1的取代基 〜8是-H; 或（2）来自植物的含大黄酸的提取物。 通式（I）中，M表示含氮有机碱或碱性氨基酸。

公开(公告)号：US06833443B1

公开(公告)日：2004-12-21

申请号：US09913322

申请日：2002-01-15

申请人： Wencai Ye ,  Yue Dai ,  Xiaodong Cong ,  Xingxiang Zhu ,  Shouxun Zhao

发明人： Wencai Ye ,  Yue Dai ,  Xiaodong Cong ,  Xingxiang Zhu ,  Shouxun Zhao

IPC分类号： C07H1500

CPC分类号： C07J63/00 ,  A61K36/27 ,  C07H15/256 ,  Y02A50/411 ,  A61K2300/00

摘要： This invention relates to new Gymnemic acid derivatives, their preparation, pharmaceutical composition or extract which contains them, and their medical use, especially the use in the prevention or treatment of the diseases associated with hyperglycemia, hyperlipidemia and platelets aggregation.

摘要翻译： 本发明涉及新的健康酸衍生物，其制备方法，含有它们的药物组合物或提取物及其医疗用途，特别是用于预防或治疗与高血糖，高脂血症和血小板聚集相关的疾病的用途。

公开(公告)号：US09181172B2

公开(公告)日：2015-11-10

申请号：US11995363

申请日：2006-07-10

申请人： Xiaodong Cong

发明人： Xiaodong Cong

IPC分类号： C07C65/34 ,  A61K31/192 ,  A61P19/02 ,  A61P3/00 ,  A61P1/00 ,  C07C66/02 ,  A61K31/197 ,  A61K31/198 ,  A61K31/4965

CPC分类号： C07C66/02 ,  A61K31/192 ,  A61K31/197 ,  A61K31/198 ,  A61K31/4965 ,  A61K2300/00

摘要： The conjugates of present invention are formed by the combination of rhein or their analogues with the organic bases or amino acids in molecular force between them. The methods for preparing the conjugates and their uses for manufacturing medicines in the treatment of diabetic nephrosis, recovery of gastrointestinal function and prevention of intestinal adhesion, as well as treatment of osteoarthritis, rheumatic arthritis and rheumatoid arthritis are also described. Rhein or their analogues as the left part of general formula (I) is selected from (1) the compounds of rhein or their analogues, in which one or two substituents of R2˜R3 and R6˜R7 are COOH at least two substituents of R1˜8 are —H; or (2) the rhein-containing extract derived from plants. In general formula (I), M represents nitrogen-containing organic bases or basic amino acids.

摘要翻译： 本发明的缀合物通过大分子蛋白或其类似物与它们之间的分子力与有机碱或氨基酸的组合形成。 还描述了制备缀合物的方法及其在治疗糖尿病肾病中的药物制备，胃肠功能恢复和肠粘连预防以及治疗骨关节炎，风湿性关节炎和类风湿性关节炎的用途。 大肠杆菌或其类似物作为通式（I）的左部分选自（1）大黄酸或其类似物的化合物，其中R 2〜R 3和R 6〜R 7的一个或两个取代基为COOH，至少两个R 1的取代基 〜8是-H; 或（2）来自植物的含大黄酸的提取物。 通式（I）中，M表示含氮有机碱或碱性氨基酸。