公开(公告)号：US20230159603A1

公开(公告)日：2023-05-25

申请号：US17995162

申请日：2021-03-31

申请人： Xilio Development, Inc.

发明人： Raphael ROZENFELD ,  Ugur ESKIOCAK ,  Huawei QIU ,  Parker JOHNSON ,  Kurt Allen JENKINS ,  Magali PEDERZOLI-RIBEIL ,  Dheeraj Singh TOMAR ,  Rebekah Kay O'DONNELL

IPC分类号： C07K14/54 ,  C07K14/715 ,  A61P35/00

CPC分类号： C07K14/5434 ,  C07K14/7155 ,  A61P35/00 ,  C07K2319/50 ,  C07K2319/30 ,  A61K38/00

摘要： The present invention relates to masked IL-12 cytokines, comprising an IL-12 cytokine or functional fragment thereof, a masking moiety and a proteolytically cleavable linker. The masking moiety masks the IL-12 cytokine or functional fragment thereof thereby reducing or preventing binding of the IL-cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the IL-12 cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.

公开(公告)号：US20230151072A1

公开(公告)日：2023-05-18

申请号：US17995163

申请日：2021-03-31

申请人： Xilio Development, Inc.

发明人： Raphael ROZENFELD ,  Ugur ESKIOCAK ,  Huawei QIU ,  Parker JOHNSON ,  Kurt Allen JENKINS ,  Magali PEDERZOLI-RIBEIL ,  Dheeraj Singh TOMAR ,  Rebekah Kay O'DONNELL

IPC分类号： C07K14/55 ,  C07K14/715 ,  A61P35/00

CPC分类号： C07K14/55 ,  C07K14/7155 ,  A61P35/00 ,  C07K2319/50 ,  C07K2319/30 ,  C07K2318/10 ,  A61K38/00

摘要： The present invention relates to masked IL-2 cytokines, comprising an IL-2 cytokine or functional fragment thereof, a masking moiety and a proteolytically cleavable linker. The masking moiety masks the IL-2 cytokine or functional fragment thereof thereby reducing or preventing binding of the IL-cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the IL-2 cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.

公开(公告)号：US20230331799A1

公开(公告)日：2023-10-19

申请号：US17995159

申请日：2021-03-31

申请人： Xilio Development, Inc.

发明人： Raphael ROZENFELD ,  Ugur ESKIOCAK ,  Huawei QIU ,  Parker JOHNSON ,  Kurt Allen JENKINS ,  Magali PEDERZOLI-RIBEIL ,  Dheeraj Singh TOMAR ,  Rebekah Kay O'DONNELL

IPC分类号： C07K14/54 ,  C07K14/715 ,  A61P35/00

CPC分类号： C07K14/5443 ,  C07K14/7155 ,  A61P35/00 ,  C07K2319/00 ,  A61K38/00

摘要： The present invention relates to masked IL-15 cytokines, comprising an IL-15 cytokine or functional fragment thereof, a masking moiety and a proteolytically cleavable linker. The masking moiety masks the IL-15 cytokine or functional fragment thereof thereby reducing or preventing binding of the IL-cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the IL-15 cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.

公开(公告)号：US20230072822A1

公开(公告)日：2023-03-09

申请号：US17535451

申请日：2021-11-24

申请人： Xilio Development, Inc.

发明人： Raphael ROZENFELD ,  Ugur ESKIOCAK ,  Huawei QIU ,  Parker JOHNSON ,  Kurt Allen JENKINS ,  Magali PEDERZOLI-RIBEIL ,  Dheeraj Singh TOMAR ,  Rebekah Kay O'DONNELL

IPC分类号： A61K47/65 ,  A61K38/20 ,  A61K47/64 ,  A61P35/00

摘要： The present disclosure provides tumor-specific cleavable linkers and their use in drugs and prodrugs for delivering therapeutics to a tumor cell environment. The present disclosure also provides cleavage products of said drugs and prodrugs, and methods related to the use of the same.