公开(公告)号：US06623732B1

公开(公告)日：2003-09-23

申请号：US09674519

申请日：2001-01-08

Applicant: Xin Fang Ma

Inventor： Xin Fang Ma

IPC: A61K900

CPC classification number: A61K38/28 ,  A61K9/0043 ,  A61K31/185 ,  A61K31/728 ,  A61K2300/00

Abstract: This invention discloses a pharmaceutical formulation for nasal administration which contains a pharmaceutically active polypeptide and a method producing the pharmaceutical formulation. The pharmaceutical for formulation comprises: (1) a pharmaceutically active polypeptide, (2) at least one compound selected from the group consisting of taurine, an ester thereof with C1˜6 alcohol, a base metal salt of taurine, hyaluronic acid and a base metal of hyaluronic acid and (3) at least one pharmacologically acceptable additive. It exhibited excellent pharmaceutical activity. No adverse effects such as irration were observed and hence, the present pharmaceutical formulation may suitably be administered nasal mucosa.

Abstract translation: 本发明公开了一种用于鼻内给药的药物制剂，其含有药物活性多肽和产生该药物制剂的方法。 药物制剂包括：（1）药学活性多肽，（2）至少一种选自牛磺酸，其与C 1-6醇的酯，牛磺酸的贱金属盐，透明质酸和贱金属的化合物 透明质酸盐和（3）至少一种药理学上可接受的添加剂。 它表现出优异的药物活性。 没有观察到不良反应如刺激，因此，本发明的药物制剂可以适当地通过鼻粘膜施用。