公开(公告)号：US20220259206A1

公开(公告)日：2022-08-18

申请号：US17568851

申请日：2022-01-05

申请人： Xinxiang Medical College ,  Anhui University of Technology

发明人： Qinghe Gao ,  Xinya Han ,  Yongtao Xu ,  Yingchao Duan ,  Jieli Lv ,  Lizhen Fang ,  Yan Zhang ,  Jufen Yan ,  Yingying Li

IPC分类号： C07D487/04

摘要： A preparation method of zaleplon is provided and belongs to the technical field of pharmaceutical chemistry. The preparation method adopts simple and cheap m-nitrobenzaldehyde and triethylamine as raw materials, and constructs a core structure of zaleplon with high efficiency and high selectivity through a one-pot series reaction without transition metal catalysis, thereby avoiding the formation of isomers, reducing the generation of by-products, increasing the yield of target products and reducing the synthesis cost; and after simple nitro reduction modification, zaleplon is prepared. The method has the advantages of short preparation route, mild reaction conditions and simple operation, so the method is suitable for industrial production.