公开(公告)号：US20120045489A1

公开(公告)日：2012-02-23

申请号：US13318548

申请日：2009-12-08

申请人： Xinyong Tong ,  Haifeng Wang ,  Shuangjin Cui ,  Li Yu

发明人： Xinyong Tong ,  Haifeng Wang ,  Shuangjin Cui ,  Li Yu

IPC分类号： A61K9/107 ,  A61P35/00 ,  A61K31/4375 ,  B82Y5/00

CPC分类号： A61K9/0019 ,  A61K9/1075 ,  A61K31/475

摘要： A nano-emulsion injection of Vinca alkaloids and its preparation method are disclosed. The injection is an oil-in-water emulsion injection comprising Vinca alkaloids or their salts, injectable oil, surfactant(s) and injectable water, wherein the average diameter of the droplets of the emulsion is less than 100 nm and the pH of the emulsion is 7-9. The preparation method comprises the steps of preparing the oil phase and the aqueous phase respectively, homogeneously mixing the oil phase and the aqueous phase with high speed, adding the active ingredient, adjusting the pH to 7-9, adding water to constant volume, and homogenizing the emulsion till the average diameter of the droplets being less than 100 nm. The alternative method comprises the steps of homogeneously mixing the oil phase and the aqueous phase, homogenizing the obtained emulsion under high pressure till the average diameter of the droplets being less than 100 nm, adding the active ingredient, adjusting the pH to 7-9, stirring, and adding water to constant volume.

摘要翻译： 公开了长春花生物碱的纳米乳液注射剂及其制备方法。 该注射剂是包含长春花生物碱或其盐，注射油，表面活性剂和可注射水的水包油乳液注射液，其中乳液的液滴的平均直径小于100nm，乳液的pH 是7-9。 制备方法包括分别制备油相和水相，高速均相混合油相和水相的步骤，加入活性成分，调节pH至7-9，加水至恒定体积， 使乳液均匀化直到液滴的平均直径小于100nm。 替代方法包括均相混合油相和水相的步骤，将所得乳液在高压下均化，直到液滴的平均直径小于100nm，加入活性成分，将pH调节至7-9， 搅拌，加水至恒定体积。