公开(公告)号：US20070134709A1

公开(公告)日：2007-06-14

申请号：US11638634

申请日：2006-12-13

申请人： Xiping Xu ,  Zhian Fang ,  Shanqun Jiang ,  Binyan Wang ,  Jianhua Yang ,  Shanchun Zhang ,  Guangyun Mao ,  Houxun Xing ,  Ping Liu ,  Yan Wang ,  Tonghua Zang ,  Mengde Wang ,  Yu Wang ,  Chengxiang Dai ,  Kerong Zhang

发明人： Xiping Xu ,  Zhian Fang ,  Shanqun Jiang ,  Binyan Wang ,  Jianhua Yang ,  Shanchun Zhang ,  Guangyun Mao ,  Houxun Xing ,  Ping Liu ,  Yan Wang ,  Tonghua Zang ,  Mengde Wang ,  Yu Wang ,  Chengxiang Dai ,  Kerong Zhang

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04 ,  A61K31/401 ,  C12M3/00

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

摘要： This invention features our discovery on usages of Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphisms in predicting homocysteine (Hcy) level and/or incidence and prognosis of diseases associated with increased Hcy level in a subject, as well as predicting treatment effects of medicines in the category of Angiotension Converting Enzyme Inhibihor (ACEI) with and without combination with B Vitamins. This invention also features our discovery on laboratory and analytical methods that are essential to the above described usages of MTHFR gene polymorphisms. In addition, this invention features a kit that has translated the above discoveries into a practical and reliable tool that can be applied to accomplish the above described usages of MTHFR gene polymorphisms. This invention represents an important step in realizing personalized medicine, with the goal to tailor diagnosis, prevention and treatment strategy to meet individual needs.

摘要翻译： 本发明的特征在于我们发现亚甲基四氢叶酸还原酶（MTHFR）基因多态性在预测同型半胱氨酸（Hcy）水平和/或与受试者中Hcy水平升高相关的疾病的发病率和预后以及预测该类药物的治疗效果 的血管紧张素转换酶抑制剂（ACEI）与B族维生素和/或B组合。 本发明还具有我们对实验室和分析方法的发现，其对于上述MTHFR基因多态性的用途是必需的。 此外，本发明的特征在于将上述发现翻译成可用于实现上述MTHFR基因多态性使用的实用且可靠的工具的试剂盒。 本发明是实现个性化医学的重要一步，目标是量身定制诊断，预防和治疗策略，以满足个人需求。