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1.发明申请2-Carboxamide Cycloamino Urea Derivatives in Combination with HSP90 Inhibitors for the Treatment of Proliferative Diseases 审中-公开2-羧酰胺环氨基脲衍生物与HSP90抑制剂联合治疗增殖性疾病公开(公告)号：US20160199365A1
公开(公告)日：2016-07-14
申请号：US15059395
申请日：2016-03-03
IPC分类号： A61K31/4439 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/16 , A61K31/235
CPC分类号： A61K31/5377 , A61K31/16 , A61K31/235 , A61K31/428 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/52 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination comprising a 2-carboxamide cycloamino urea derivative compound of formula (I) and inhibitors of Heat Shock Protein 90, and the uses of such combinations in the treatment of proliferative diseases, more specifically PI3K dependent diseases, more specifically PI3K-alpha dependent diseases.
摘要翻译： 本发明涉及包含式（I）的2-甲酰胺环氨基脲衍生物化合物和热休克蛋白90抑制剂的药物组合，以及这些组合在治疗增殖性疾病中的用途，更具体地说是PI3K依赖性疾病 特别是PI3K-α依赖性疾病。
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2.发明申请Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members 审中-公开使用2-甲酰胺环氨基脲衍生物治疗EGFR依赖性疾病或已获得耐药性靶向EGFR家族成员的疾病公开(公告)号：US20130209461A1
公开(公告)日：2013-08-15
申请号：US13879644
申请日：2011-11-07
申请人： Saskia Maria Brachmann , Christine Fritsch , Sauveur-Michel Maira , Christian Rene Schnell , Carlos Garcia-Echeverria
发明人： Saskia Maria Brachmann , Christine Fritsch , Sauveur-Michel Maira , Christian Rene Schnell , Carlos Garcia-Echeverria
IPC分类号： A61K31/4439 , A61K31/517 , A61K39/395
CPC分类号： A61K31/4439 , A61K31/517 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2300/00 , C07K16/32 , C07K2317/24
摘要： A method for treating an Epidermal Growth Factor Receptor (EGFR) dependent diseases or diseases that have acquired resistance to agents that target EGFR family members comprising administering a therapeutically effective amount of a compound of formula (I) alone or in combination with an EGFR modulator, to a warm-blooded animal in need thereof; combinations comprising the compound of formula (I) and an EGFR modulator for the treatment of said diseases; and pharmaceutical preparations for the treatment of said diseases comprising the compound of formula (I), alone or in combination with an EGFR modulator.
摘要翻译： 一种用于治疗具有针对EGFR家族成员的药物获得抗性的表皮生长因子受体（EGFR）依赖性疾病或疾病的方法，包括单独或与EGFR调节剂组合施用治疗有效量的式（I）化合物， 到有需要的温血动物; 包含式（I）化合物和用于治疗所述疾病的EGFR调节剂的组合; 和用于治疗包含式（I）化合物的所述疾病的药物制剂，其单独或与EGFR调节剂组合。
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3.发明申请DOSAGE REGIMEN FOR AN ALPHA-ISOFORM SELECTIVE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR 审中-公开用于ALPHA-ISOFORM选择性磷脂酰肌醇3激酶抑制剂的剂量公开(公告)号：US20170000778A1
公开(公告)日：2017-01-05
申请号：US15101155
申请日：2014-12-03
申请人： Emmanuelle di Tomaso , Marie-Caroline Germa , Cristian Massacesi , Christine Fritsch , Christian Rene Schnell , Ranjana Tavorath
发明人： Emmanuelle di Tomaso , Marie-Caroline Germa , Cristian Massacesi , Christine Fritsch , Christian Rene Schnell , Ranjana Tavorath
IPC分类号： A61K31/4439 , A61K9/00
CPC分类号： A61K31/4439 , A61K9/0053
摘要： The present invention relates to methods of treating or preventing a proliferative disease in a patient in need thereof by orally administering a therapeutically effective amount of an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor compound of formula (I) or a pharmaceutically acceptable salt thereof for at least two five-consecutive day cycle, wherein said compound is not administered to the patient for a period of about two days to about three days between said five-consecutive day cycles; the use of said compound of formula (I) or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for treating or preventing a proliferative disease administered in accordance with said dosage regimen; therapeutic regimen comprising administration of said compound of formula (I) or a pharmaceutically acceptable salt thereof in accordance with said dosage regimen; and related pharmaceutical compositions and packages thereof.
摘要翻译： 本发明涉及通过口服施用治疗有效量的式（I）的α-同种型选择性磷脂酰肌醇3-激酶抑制剂化合物或其药学上可接受的盐来治疗或预防有需要的患者中的增殖性疾病的方法 至少两个连续五天的周期，其中所述化合物在所述五个连续的日期周期之间不经由所述患者施用约两天至约三天的时间; 所述式（I）化合物或其药学上可接受的盐在制备用于治疗或预防根据所述剂量方案施用的增殖性疾病的药物中的用途; 治疗方案包括根据所述剂量方案施用所述式（I）化合物或其药学上可接受的盐; 及其相关的药物组合物和包装。
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4.发明授权Short interfering ribonucleic acid (siRNA) with improved pharmacological properties 有权短干扰核糖核酸（siRNA）具有改善的药理学性质公开(公告)号：US08084600B2
公开(公告)日：2011-12-27
申请号：US12299396
申请日：2007-05-02
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/332 , C12N2310/346 , C12N2310/3529 , C12N2310/50 , C12N2310/3521 , C12N2310/3533 , C12N2310/3525
摘要： Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification.
摘要翻译： 用于口服给药的短干扰核糖核酸（siRNA），所述siRNA包含在至少15个核苷酸上彼此互补的两个单独的RNA链，其中每条链是49个核苷酸或更少，并且其中至少一个链含至少 一种化学改性。
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公开(公告)号：US08404832B2
公开(公告)日：2013-03-26
申请号：US13218880
申请日：2011-08-26
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/332 , C12N2310/346 , C12N2310/3529 , C12N2310/50 , C12N2310/3521 , C12N2310/3533 , C12N2310/3525
摘要： Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification.
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公开(公告)号：US08344128B2
公开(公告)日：2013-01-01
申请号：US13218941
申请日：2011-08-26
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/332 , C12N2310/346 , C12N2310/3529 , C12N2310/50 , C12N2310/3521 , C12N2310/3533 , C12N2310/3525
摘要： Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification.
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7.发明申请MEANS FOR PREVENTING THE ROTATION OF A PIN SUPPORTING A TURBINE ENGINE SUSPENSION MEMBER 有权用于防止支撑涡轮发动机悬架部件的销的旋转的手段公开(公告)号：US20090134270A1
公开(公告)日：2009-05-28
申请号：US12265198
申请日：2008-11-05
IPC分类号： B64D27/00
CPC分类号： B64D27/26 , B64D2027/266
摘要： The present invention relates to a device for mounting a suspension member on the casing of a turbine engine comprising a yoke with at least one lug, secured to the casing, a pin fixed to said yoke supporting said member via a ring surrounding the pin, said device comprising a rotation-prevention means comprising a counter-rotation plate attached to the lug. The device is one wherein said plate and the pin comprise an assembly consisting of a peg and of a cutout or a hole, into which said peg fits in order to prevent the pin from rotating in the yoke.
摘要翻译： 本发明涉及一种用于将悬挂构件安装在涡轮发动机的壳体上的装置，其包括具有至少一个凸耳的轭，固定到壳体，固定到所述轭的销，所述轭经由围绕销的环支撑所述构件，所述 该装置包括旋转防止装置，该防止装置包括附接到凸耳的反向旋转板。 该装置是其中所述板和销包括由栓钉和切口或孔组成的组件，其中所述钉匹配以便防止销在轭中旋转。
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公开(公告)号：US09493771B2
公开(公告)日：2016-11-15
申请号：US14177640
申请日：2014-02-11
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/332 , C12N2310/346 , C12N2310/3529 , C12N2310/50 , C12N2310/3521 , C12N2310/3533 , C12N2310/3525
摘要： Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification.
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公开(公告)号：US08277176B2
公开(公告)日：2012-10-02
申请号：US12048505
申请日：2008-03-14
CPC分类号： F01D25/30 , F01D25/32 , F05D2250/231 , F05D2260/602
摘要： A turbomachine exhaust case having an annular groove perforated with an orifice in which there is mounted a drain, which is formed by a tubular cylindrical body, for discharging liquids retained in this groove is disclosed. The drain includes a skirt, formed at one end of the cylindrical body, for fastening the drain by crimping in the orifice in the groove of the case.
摘要翻译： 公开了一种涡轮机排气箱，其具有穿孔的环形槽，其中安装有由管状圆柱体形成的排水口，用于排放保留在该槽中的液体。 排水口包括形成在圆筒体的一端的裙部，用于通过卷曲在壳体的槽中的孔口中来紧固排水口。
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公开(公告)号：US20080307795A1
公开(公告)日：2008-12-18
申请号：US12139089
申请日：2008-06-13
申请人： Valentine BADER , Laurent Pierre Elysee Gaston Marnas , Nicolas Pommier , Christian Rene Schnell
发明人： Valentine BADER , Laurent Pierre Elysee Gaston Marnas , Nicolas Pommier , Christian Rene Schnell
CPC分类号： F02C7/00 , F01D25/30 , F02C7/20 , F05D2250/70 , F05D2260/941
摘要： An exhaust casing hub comprises a hub center (6), and an upstream flange (8) and a downstream flange (10) arranged on either side of the hub center. Each flange is terminated by a rim (12). A plurality of cuffs (14) are arranged on the hub center (6) so as to form an angle from the tangent toward the radial direction of 10° to 80°, preferably 15° to 75°. At least one rib is formed at the base of each cuff (14) below a critical stress region (26) in the cuff. The rib is joined to the downstream flange by a downstream end and to the upstream flange by an upstream end.
摘要翻译： 排气套管毂包括轮毂中心（6）和布置在轮毂中心两侧的上游法兰（8）和下游法兰（10）。 每个凸缘由边缘（12）端接。 在轮毂中心（6）上设置有多个袖带（14），从而形成从切线朝向径向的角度为10°〜80°，优选为15°〜75°。 在袖带内的临界应力区域（26）下方的每个箍（14）的基部处形成至少一个肋。 肋通过下游端连接到下游凸缘，并通过上游端连接到上游凸缘。
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