公开(公告)号：US20160166612A1

公开(公告)日：2016-06-16

申请号：US14898732

申请日：2014-05-22

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Inventor： Michal EISENBACH-SCHWARTZ ,  Ester YOLES ,  Inbal BENHAR BAR-ON

IPC: A61K35/15 ,  A61K9/00

CPC classification number: A61K35/15 ,  A61K9/0048 ,  A61K35/17 ,  A61K39/0008 ,  A61K2035/122 ,  A61K2039/5154 ,  C12N5/0645

Abstract: A monocyte subpopulation having a low relative amount, or substantially devoid, of CD3+ cells, CD19+ cells, CD56+ cells and optionally CD16+ cells is provided, wherein the monocyte subpopulation is for use in inhibition of neuronal degeneration, protection of neurons from glutamate toxicity or promotion of nerve regeneration in the retina or optic nerve, wherein the retina or optic nerve is damaged by a disease, disorder or condition of the eye, or for treatment of an inflammatory disease, disorder or condition of the eye.

Abstract translation: 提供了具有低相对量或基本上不含CD3 +细胞，CD19 +细胞，CD56 +细胞和任选的CD16 +细胞的单核细胞亚群，其中所述单核细胞亚群用于抑制神经元变性，保护神经元免于谷氨酸毒性或促进 在视网膜或视神经中的神经再生，其中视网膜或视神经被眼睛的疾病，病症或状况损伤，或用于治疗眼睛的炎性疾病，病症或病症。