公开(公告)号：US20170307625A1

公开(公告)日：2017-10-26

申请号：US15640545

申请日：2017-07-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MARGULIES ,  Leila MOTIEI ,  Linor UNGER

IPC: G01N33/58 ,  C07D417/14 ,  C09K11/06 ,  C07D417/06 ,  G01N33/573 ,  C07K7/06 ,  G01N33/574

CPC classification number: G01N33/582 ,  C07D417/06 ,  C07D417/14 ,  C07F9/65583 ,  C07K7/06 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/23 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/1037 ,  C12N9/1088 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/91177 ,  G01N2333/918 ,  G01N2333/96494

Abstract: The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.