公开(公告)号：US20210156867A1

公开(公告)日：2021-05-27

申请号：US17140075

申请日：2021-01-03

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MARGULIES ,  Leila MOTIEI ,  Pragati PRASAD ,  Tom GRANOT ,  Ohad SUSS

IPC: G01N33/58 ,  G01N33/68 ,  G01N21/64 ,  G01N33/50

Abstract: This invention is directed to a turn-on fluorescent probe, wherein said probe comprises a quinoline based cyanine dye derivative (QBC) and a specific protein binder covalently attached thereto directly or via a linker. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further describes methods for using these turn-on probes and compounds for detecting and labelling a wide range of proteins in their native environment.