公开(公告)号：US20240376213A1

公开(公告)日：2024-11-14

申请号：US18692039

申请日：2022-09-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ido AMIT ,  Rony DAHAN ,  Yuval SHAPIR ,  Oren BARBOY

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K16/46

Abstract: A multispecific antibody is provided. The antibody comprises a first antigen binding moiety, which specifically binds to an immune checkpoint protein on intratumor T cells and a second antigen binding moiety which specifically binds to a conventional dendritic cell 1 (cDC1). Also provided are uses of such antibodies in cancer treatment.