公开(公告)号：US20220204928A1

公开(公告)日：2022-06-30

申请号：US17604169

申请日：2020-04-16

申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  ICHILOV TECH LTD.

发明人： Anat AHARON ,  Anat GLOBERSON LEVIN ,  Irit AVIVI ,  Galit HORN ,  Tova WAKS ,  Zelig ESHHAR

IPC分类号： C12N5/0783 ,  C07K16/32 ,  C07K14/705 ,  C07K14/725 ,  A61K45/06 ,  A61K39/395 ,  A61K38/17 ,  A61P35/00 ,  A61K35/17 ,  C07K16/28

摘要： The present invention provides extracellular vesicles (EVs) derived from T-cells expressing chimeric antigen receptors (CAR) specifically activated with an antigen to which the CAR bind specifically, pharmaceutical compositions comprising these vesicles as well as their use in treating cancer. In particular the present invention exemplifies EVs derived from activated T-cells expressing CAR that bind specifically to HER2 cancer antigen, pharmaceutical composition comprising these EVs and their use in treating a cancer overexpressing HER2, such as ovarian cancer and breast cancer.