公开(公告)号：US3710117A

公开(公告)日：1973-01-09

申请号：US3710117D

申请日：1970-04-27

Applicant: YISSUM RES DEV CO

Inventor： GROSS J ,  GORDON A

IPC: G01N33/78 ,  G21H5/00

CPC classification number: G01N33/78 ,  Y10S436/804

Abstract: Improved in vitro test method and apparatus for assessing thyroid function comprising mixing a microquantity of blood serum with a predetermined amount of a radioactive isotope tagged thyroid hormone solution in the upper portion of a tubular body having a fixed geometry, said body containing a column of predetermined quantity of cross linked dextran gel as a secondary binding site in an aqueous fluid held between porous discs in the lower portion of the body and having valve means at the lower end thereof, allowing said mixture to enter said column, determining the total added thyroid hormone by a radioactivity measurement, washing or eluting said column with a suitable fluid, determining the amount of hormone retained in said column by a radioactivity measurement and making a calculation based on the ratio of the amount of retained hormone to the total amount of added hormone for the particular thyroid hormone being assessed.

Abstract translation: 用于评估甲状腺功能的改进的体外试验方法和装置，包括将具有固定几何形状的管状体的上部中的血清微量量与预定量的放射性同位素标记的甲状腺激素溶液混合，所述体包含预定的柱 交联的葡聚糖凝胶的量作为在身体下部保持在多孔盘之间的水性流体中的二级结合位点，并且在其下端具有阀装置，允许所述混合物进入所述柱，确定总添加的甲状腺激素 通过放射性测量，用合适的流体洗涤或洗脱所述柱，通过放射性测量确定所述柱中保留的激素的量，并且基于保留的激素的量与加入的激素的总量的比例进行计算 正在评估特定的甲状腺激素。