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公开(公告)号:US20180111918A1
公开(公告)日:2018-04-26
申请号:US15848760
申请日:2017-12-20
申请人: YUHAN CORPORATION
发明人: Hyun-Joo LEE , Dong-Hoon KIM , Tae-Kyun KIM , Young-Ae YOON , Jae-Young SIM , Myung-Hun CHA , Eun-Jung JUNG , Kyoung-Kyu AHN , Tai-Au LEE
IPC分类号: C07D403/04 , C07D413/14 , C07D413/04 , C07D417/04 , C07D401/04
CPC分类号: C07D403/04 , C07D401/04 , C07D413/04 , C07D413/14 , C07D417/04
摘要: The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.
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公开(公告)号:US20180072705A1
公开(公告)日:2018-03-15
申请号:US15813741
申请日:2017-11-15
申请人: Yuhan Corporation
发明人: Hyun-Joo LEE , Dong-Hoon KIM , Tae-Kyun KIM , Young-Ae YOON , Jae-Young SIM , Myung-Hun CHA , Eun-Jung JUNG , Kyoung-Kyu AHN , Tai-Au LEE
IPC分类号: C07D403/04 , C07D417/04 , C07D413/14 , C07D401/04 , C07D413/04
CPC分类号: C07D403/04 , C07D401/04 , C07D413/04 , C07D413/14 , C07D417/04
摘要: The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.
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