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公开(公告)号:US11136364B2
公开(公告)日:2021-10-05
申请号:US15768865
申请日:2016-10-28
申请人: YUHAN CORPORATION
发明人: Jun Hwan Kim , Seyoung Lim , Minji Seo , Hyun Ho Choi , Dohoon Kim , Mi Kyeong Ju , Ju-Young Park , Seul Gi Kim , Sangmyoun Lim , Jong Gyun Kim , Su Youn Nam
IPC分类号: A61K38/18 , C07K14/50 , C07K14/575 , C07K14/605
摘要: The present invention provides a dual function protein prepared by linking a biologically active protein and an FGF mutant protein to an Fc region of an immunoglobulin, which has improved pharmacological efficacy, in vivo duration and protein stability. A dual function protein according to the present invention exhibits improved pharmacological efficacy, in vivo duration and protein stability, and a pharmaceutical composition containing the dual function protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis or cardiovascular diseases.