公开(公告)号：US20190314452A1

公开(公告)日：2019-10-17

申请号：US16348249

申请日：2017-11-10

Applicant: YUHAN CORPORATION

Inventor： Han Na HONG ,  Jun Hwan KIM ,  Hyun Ho CHOI ,  Dohoon KIM ,  Taewang KIM ,  Se Woong OH ,  Moo Young SONG ,  Jong Gyun KIM

IPC: A61K38/18 ,  A61K38/26 ,  A61K38/17 ,  A61P1/16

Abstract: The present invention provides a composition for preventing or treating hepatitis, hepatic fibrosis, and hepatic cirrhosis. Specifically, the present invention provides a fusion protein comprising a biologically active protein and an FGF21 mutant protein; and a pharmaceutical composition containing the fusion protein, which is effective for preventing or treating hepatitis, hepatic fibrosis, and hepatic cirrhosis. A pharmaceutical composition of the present invention has the effect of inhibiting proliferation of inflammatory cells and fibroblasts, and thus can be effectively used as a composition for preventing or treating hepatitis, hepatic fibrosis, and hepatic cirrhosis.