专利检索 ap:("YUHAN CORPORATION" OR "INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY") AND inv:"Cheol Ryong Ku" 第 1 页

1.

发明授权
Fusion protein comprising thyrotropin receptor variants and use thereof 有权

公开(公告)号：US11479596B2

公开(公告)日：2022-10-25

申请号：US17256296

申请日：2019-07-24

申请人： YUHAN CORPORATION , INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

发明人： Moo Young Song , Taejin Yoon , Jung-Sun Lee , Byung Hyun Choi , In Hwan Lim , Man Sil Park , Jin-Hyoung Lee , Hyoung Sig Seo , Hyeon Woo Kang , Sung Ho Kim , Eun Jig Lee , Jin Sook Yoon , Cheol Ryong Ku

IPC分类号： A61K38/17 , A61K47/68 , C07K14/72 , C07K19/00 , A61K47/64 , A61K38/00

摘要： Disclosed are a fusion protein comprising a thyrotropin receptor (TSHR) fragment and the use thereof. More specifically, disclosed are a fusion protein comprising a TSHR fragment comprising an extracellular domain of a wild-type TSHR and having a substitution of an amino acid at specific position and an immunoglobulin Fc region or a carboxy-terminal cap (C-CAP), and the use thereof. The fusion protein has improved pharmaceutical efficacy, in-vivo persistence and protein stability and a pharmaceutical composition containing the fusion protein as an active ingredient is useful as a therapeutic agent or diagnostic reagent for the alleviation of Graves' disease and Graves' ophthalmopathy.